ECM2/YBR065C Summary Help

Standard Name ECM2 1
Systematic Name YBR065C
Alias SLT11 2
Feature Type ORF, Verified
Description Pre-mRNA splicing factor; facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p (2, 3, 4)
Name Description ExtraCellular Mutant 1
Chromosomal Location
ChrII:369678 to 368584 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ECM2 GO evidence and references
  View Computational GO annotations for ECM2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
unspecified
Resources
164 total interaction(s) for 116 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 47
  • Affinity Capture-Western: 1
  • Co-purification: 1

Genetic Interactions
  • Negative Genetic: 96
  • Positive Genetic: 8
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 364
Molecular Weight (Da) 40,924
Isoelectric Point (pI) 10.24
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:369678 to 368584 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1095 369678..368584 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000269
References cited on this page View Complete Literature Guide for ECM2
1) Lussier M, et al.  (1997) Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Genetics 147(2):435-50
2) Xu D, et al.  (1998) Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing. Mol Cell Biol 18(4):2055-66
3) Ben-Yehuda S, et al.  (2000) Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae. Genetics 156(4):1503-17
4) Xu D and Friesen JD  (2001) Splicing factor slt11p and its involvement in formation of U2/U6 helix II in activation of the yeast spliceosome. Mol Cell Biol 21(4):1011-23