Standard Name	PRP6
Systematic Name	YBR055C
Alias	RNA6 , TSM7269
Feature Type	ORF, Verified
Description	Splicing factor, component of the U4/U6-U5 snRNP complex (1)
Name Description	Pre-mRNA Processing 2

Chromosomal Location	ChrII:347301 to 344602 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 33 cM

	View Computational GO annotations for PRP6
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	mRNA splicing, via spliceosome (IPI)
Cellular Component
Manually curated	U4/U6 x U5 tri-snRNP complex (IDA)

Classical genetics
conditional	cold sensitivity: increased heat sensitivity: increased sporulation: absent
null	inviable
Large-scale survey
conditional	colony sectoring: increased
null	haploinsufficient inviable
reduction of function	competitive fitness: increased
repressible	cell cycle progression in G2 phase: abnormal chromosome/plasmid maintenance: decreased cytokinesis: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	186 total interaction(s) for 130 unique genes/features.
Physical Interactions	Affinity Capture-MS: 132 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 4 Co-purification: 4 Two-hybrid: 6
Genetic Interactions	Negative Genetic: 33 Positive Genetic: 1 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:347301 to 344602 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 33 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2700 347301..344602 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000259