GIP1/YBR045C Summary Help

Standard Name GIP1 1
Systematic Name YBR045C
Feature Type ORF, Verified
Description Meiosis-specific regulatory subunit of the Glc7p protein phosphatase; regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p (1, 2 and see Summary Paragraph)
Name Description Glc7-Interacting Protein 1
Chromosomal Location
ChrII:330092 to 328173 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All GIP1 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
overexpression
unspecified
Resources
32 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Two-hybrid: 6

Genetic Interactions
  • Negative Genetic: 17
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 639
Molecular Weight (Da) 73,354
Isoelectric Point (pI) 4.84
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:330092 to 328173 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1920 330092..328173 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000249
SUMMARY PARAGRAPH for GIP1

Gip1p is a regulatory protein for the Glc7p type-1 protein phosphatase (PP1), and is required for normal localization of Glc7p during meiosis (2). The Gip1p-Glc7p phosphatase complex regulates septin organization and spore wall formation (2). GIP1 is also required for the expression of some late meiotic genes, including DIT1 and SPS100 (3). GIP1 is transcribed in an Ime1p-dependent manner during meiosis (3, 1), at which time Gip1p and Glc7p colocalize with the septins in structures underlying the growing prospore membranes (2).

gip1 haploid null mutants are viable, but homozygous diploid null mutants are unable to sporulate (1). Meiotic progression is normal in gip1 nulls, but Glc7p and septins display abnormal localization, and spore wall assembly is compromised (2).

Last updated: 2005-10-10 Contact SGD

References cited on this page View Complete Literature Guide for GIP1
1) Tu J, et al.  (1996) Protein phosphatase type 1 interacts with proteins required for meiosis and other cellular processes in Saccharomyces cerevisiae. Mol Cell Biol 16(8):4199-206
2) Tachikawa H, et al.  (2001) A Gip1p-Glc7p phosphatase complex regulates septin organization and spore wall formation. J Cell Biol 155(5):797-808
3) Ramaswamy NT, et al.  (1998) Regulation of yeast glycogen metabolism and sporulation by Glc7p protein phosphatase. Genetics 149(1):57-72