Standard Name	CDS1
Systematic Name	YBR029C
Alias	CDG1
Feature Type	ORF, Verified
Description	Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids (1, 2)
Name Description	CDP-Diacylglycerol Synthase 2

Chromosomal Location	ChrII:297742 to 296369 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for CDS1
Molecular Function
Manually curated	phosphatidate cytidylyltransferase activity (IDA)
Biological Process
Manually curated	CDP-diacylglycerol biosynthetic process (IMP) phosphatidylinositol metabolic process (IMP) phosphatidylserine metabolic process (IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) Golgi to plasma membrane transport vesicle (IDA)
High-throughput	integral to membrane (ISM)

Pathways	CDP-diacylglycerol biosynthesis phosphatidic acid and phospholipid biosynthesis

Classical genetics
null	myo-inositol excretion: increased endoplasmic reticulum morphology: abnormal
Large-scale survey
conditional	heat sensitivity: increased
null	haploproficient inviable lipid particle morphology: abnormal
overexpression	vegetative growth: decreased vegetative growth: decreased rate
reduction of function	competitive fitness: increased resistance to sirolimus: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	16 total interaction(s) for 16 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 PCA: 1 Protein-RNA: 1 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 4 Positive Genetic: 1 Synthetic Growth Defect: 4 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:297742 to 296369 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1374 297742..296369 2004-07-16 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000233