CHS3/YBR023C Summary Help

Standard Name CHS3 1 (see Nomenclature conflict Note)
Systematic Name YBR023C
Alias CAL1 2 , CSD2 , DIT101 , KTI2 3
Feature Type ORF, Verified
Description Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan (4, 5, 6, 7)
Name Description CHitin Synthase-related 7
Chromosomal Location
ChrII:287925 to 284428 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 9 cM
Gene Ontology Annotations All CHS3 GO evidence and references
  View Computational GO annotations for CHS3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Pathways
Mutant phenotypes All CHS3 Phenotype evidence and references
Classical genetics
null
reduction of function
unspecified
Large-scale survey
null
overexpression
Resources
interactions All CHS3 Interaction evidence and references
258 total interaction(s) for 144 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 9
  • Co-purification: 1
  • PCA: 15
  • Two-hybrid: 7
Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 2
  • Negative Genetic: 54
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 2
  • Positive Genetic: 1
  • Synthetic Growth Defect: 56
  • Synthetic Lethality: 97
  • Synthetic Rescue: 2
Resources
Expression Summary
histogram
Resources
Protein Information All CHS3 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:287925 to 284428 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: 9 cM
Last Update Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3498 287925..284428 2004-07-16 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000227

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
CDC43Nomenclature conflictCAL1 has been used to refer to both CDC43/YGL155W, which encodes a subunit of protein geranylgeranyltransferase, and CHS3/YBR023C, which encodes chitin synthase 3.
References cited on this page View Complete Literature Guide for CHS3
1) Breitenbach, M.  (1992) Personal Communication, Mortimer Map Edition 11
2) Takita MA and Castilho-Valavicius B  (1993) Absence of cell wall chitin in Saccharomyces cerevisiae leads to resistance to Kluyveromyces lactis killer toxin. Yeast 9(6):589-98
3) Butler AR, et al.  (1991) Intracellular expression of Kluyveromyces lactis toxin gamma subunit mimics treatment with exogenous toxin and distinguishes two classes of toxin-resistant mutant. Yeast 7(6):617-25
4) Ziman M, et al.  (1996) Chs1p and Chs3p, two proteins involved in chitin synthesis, populate a compartment of the Saccharomyces cerevisiae endocytic pathway. Mol Biol Cell 7(12):1909-19
5) Shaw JA, et al.  (1991) The function of chitin synthases 2 and 3 in the Saccharomyces cerevisiae cell cycle. J Cell Biol 114(1):111-23
6) Pammer M, et al.  (1992) DIT101 (CSD2, CAL1), a cell cycle-regulated yeast gene required for synthesis of chitin in cell walls and chitosan in spore walls. Yeast 8(12):1089-99
7) Cid VJ, et al.  (1995) Molecular basis of cell integrity and morphogenesis in Saccharomyces cerevisiae. Microbiol Rev 59(3):345-86