KAP104/YBR017C Summary Help

Standard Name KAP104 1
Systematic Name YBR017C
Feature Type ORF, Verified
Description Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis (1, 2, 3, 4)
Name Description KAryoPherin 1
Chromosomal Location
ChrII:273703 to 270947 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All KAP104 GO evidence and references
  View Computational GO annotations for KAP104
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
Resources
126 total interaction(s) for 79 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 76
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 11
  • Co-localization: 1
  • Co-purification: 2
  • Protein-peptide: 2
  • Reconstituted Complex: 18
  • Two-hybrid: 8

Genetic Interactions
  • Synthetic Lethality: 1
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 918
Molecular Weight (Da) 103,680
Isoelectric Point (pI) 4.34
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:273703 to 270947 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2757 273703..270947 2004-07-16 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000221
References cited on this page View Complete Literature Guide for KAP104
1) Aitchison JD, et al.  (1996) Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274(5287):624-7
2) Lee DC and Aitchison JD  (1999) Kap104p-mediated nuclear import. Nuclear localization signals in mRNA-binding proteins and the role of Ran and Rna. J Biol Chem 274(41):29031-7
3) Seedorf M and Silver PA  (1997) Importin/karyopherin protein family members required for mRNA export from the nucleus. Proc Natl Acad Sci U S A 94(16):8590-5
4) van den Bogaart G, et al.  (2009) Nuclear transport factor directs localization of protein synthesis during mitosis. Nat Cell Biol 11(3):350-6