RTG3/YBL103C Summary

RTG3 BASIC INFORMATION

Standard Name	RTG3
Systematic Name	YBL103C
Feature Type	ORF, Verified
Description	Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways (1, 2)
Name Description	ReTroGrade regulation 3

GO Annotations	All RTG3 GO evidence and references
	View Computational GO annotations for RTG3
Molecular Function
Manually curated	specific RNA polymerase II transcription factor activity (IDA)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	mitochondrial signaling pathway (IDA) transcription initiation from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Regulatory Role
Binding motifs	RTG3 Transcription Factor Binding Sites and References
	GGTCAC

Mutant Phenotype	All RTG3 Phenotype details and references
Classical genetics
null	auxotrophy resistance to hydroxyurea: decreased resistance to rapamycin: increased utilization of carbon source: decreased
Large-scale survey
null	hyperosmotic stress resistance: decreased resistance to wortmannin: decreased resistance to rapamycin: increased resistance to hydroxyurea: decreased resistance to ethanol: decreased viable

Interactions	RTG3 All interactions details and references
	86 total interaction(s) for 71 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 1 Reconstituted Complex: 2 Two-hybrid: 5
Genetic Interactions	Phenotypic Enhancement: 35 Phenotypic Suppression: 30 Synthetic Growth Defect: 1 Synthetic Lethality: 3 Synthetic Rescue: 2

Sequence Information

ChrII:23535 to 22075 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-01-26 | Sequence: 1997-07-27

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1461	23535..22075	2004-01-26	1997-07-27

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000199

RTG3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RTG3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RTG3]

1)	Rothermel BA, et al. (1997) Rtg3p, a basic helix-loop-helix/leucine zipper protein that functions in mitochondrial-induced changes in gene expression, contains independent activation domains. J Biol Chem 272(32):19801-7
2)	Crespo JL, et al. (2002) The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc Natl Acad Sci U S A 99(10):6784-9
3)	Jia Y, et al. (1997) A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signaling pathway from mitochondria to the nucleus. Mol Cell Biol 17(3):1110-7

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