TEL1/YBL088C Summary Help

Standard Name TEL1 1
Systematic Name YBL088C
Feature Type ORF, Verified
Description Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585) (2, 3, 4, 5, 6 and see Summary Paragraph)
Name Description TELomere maintenance 1
Chromosomal Location
ChrII:59382 to 51019 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -60 cM
Gene Ontology Annotations All TEL1 GO evidence and references
  View Computational GO annotations for TEL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant phenotypes All TEL1 Phenotype evidence and references
Classical genetics
conditional
null
overexpression
Large-scale survey
null
Resources
interactions All TEL1 Interaction evidence and references
216 total interaction(s) for 123 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-Western: 7
  • Biochemical Activity: 6
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Growth Defect: 12
  • Dosage Lethality: 3
  • Dosage Rescue: 6
  • Negative Genetic: 41
  • Phenotypic Enhancement: 67
  • Phenotypic Suppression: 15
  • Positive Genetic: 5
  • Synthetic Growth Defect: 36
  • Synthetic Lethality: 3
  • Synthetic Rescue: 8
Resources
Expression Summary
histogram
Resources
Protein Information All TEL1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:59382 to 51019 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -60 cM
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..8364 59382..51019 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000184
SUMMARY PARAGRAPH for TEL1

TEL1 was originally identified in a mutant screen to find genes involved in maintaining telomere length (1). It was later shown that Tel1p is a phosphatidylinositol 3-kinase homolog and is related to the human ATM (ataxia telangiectasia mutated) gene (7, 8). However, despite its similarity to phosphatidylinositol 3-kinases, Tel1p has been shown to have protein kinase activity (9). Ataxia-telangiectasia (AT) is an autosomal recessive disorder that causes cerebellar ataxia, telangiectases, immune defects, and a predisposition to cancer; AT cells are hypersensitive to killing by ionizing radiation (OMIM:607585). Tel1p is a member of the PIK-related kinase family that includes Mec1p, Tor1p, and Tor2p and is involved in DNA repair, recombination, and regulation of the cell cycle (10, 11).

Last updated: 2005-05-27

References cited on this page View Complete Literature Guide for TEL1
1) Lustig AJ and Petes TD  (1986) Identification of yeast mutants with altered telomere structure. Proc Natl Acad Sci U S A 83(5):1398-402
2) Ritchie KB and Petes TD  (2000) The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. Genetics 155(1):475-9
3) Craven RJ, et al.  (2002) Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics 161(2):493-507
4) Giannattasio M, et al.  (2002) A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1. Proc Natl Acad Sci U S A 99(20):12997-3002
5) Nakada D, et al.  (2003) The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment. Nucleic Acids Res 31(6):1715-24
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Greenwell PW, et al.  (1995) TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82(5):823-9
8) Morrow DM, et al.  (1995) TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82(5):831-40
9) Mallory JC and Petes TD  (2000) Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase. Proc Natl Acad Sci U S A 97(25):13749-54
10) Keith CT and Schreiber SL  (1995) PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science 270(5233):50-1
11) Jackson SP  (1996) The recognition of DNA damage. Curr Opin Genet Dev 6(1):19-25