NUP170/YBL079W Summary 
NUP170 BASIC INFORMATION
| Standard Name | NUP170 |
|---|---|
| Systematic Name | YBL079W |
| Alias | NLE3 |
| Feature Type | ORF, Verified |
| Description | Subunit of the nuclear pore complex (NPC), required for NPC localization of specific nucleoporins; involved in nuclear envelope permeability and chromosome segregation; has similar to Nup157p; essential role, with Nup157p, in NPC assembly (1, 2, 3, 4, 5, 6 and see Summary Paragraph) 
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| Name Description | NUclear Pore |
| GO Annotations | All NUP170 GO evidence and references |
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| View Computational GO annotations for NUP170 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated |
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| Cellular Component | |
| Manually curated |
| Interactions | NUP170 All interactions details and references |
|---|---|
| 109 total interaction(s) for 85 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB |
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| Primary SGDID | S000000175 |
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NUP170 RESOURCES
| SGD ORF map | GBrowse |
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Click on histogram for expression summary
Expression Summary
ADDITIONAL INFORMATION for NUP170
SUMMARY PARAGRAPH for NUP170
NUP170 encodes a nuclear pore protein (4, 7). Transport of macromolecules between the nucleus and the cytoplasm of eukaryotic cells occurs through the nuclear pore complex (NPC), a large macromolecular complex that spans the nuclear envelope (reviewed in 7, 8, 9, 10). The structure of the vertebrate NPC has been studied extensively; recent reviews include 11, 12, 13, and 14. The yeast NPC shares several features with the vertebrate NPC, despite being smaller and less elaborate (15, 16). Many yeast nuclear pore proteins, or nucleoporins, have been identified by a variety of genetic approaches (reviewed in 7, 8, 17, 18, 19). Nup170p is one of the most abundant yeast nucleoporins (4). Nup170p interacts physically with other abundant yeast nucleoporins, Nic96p, Pom152p, Nup157p, and Nup188p (20, 7). These abundant nucleoporins may form the structural core of the NPC (7). Also, Nup170p forms a complex with the nucleoporins Nup53p and Asm4p (21). The complex is found on both the nuclear and cytoplasmic faces of the NPC, and associates with Pse1p, a member of a protein family implicated in nuclear protein import. Nup157p and Nup170p are very similar to each other and to a mammalian nucleoporin, Nup155 (4, 2, 7). NUP170 is not essential, but nup170 mutations are synthetically lethal with mutations in several other nucleoporin genes (22, 7).
Last updated: 1999-08-12
REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NUP170]
| 1) | Shulga N, et al. (2000) Yeast nucleoporins involved in passive nuclear envelope permeability. J Cell Biol 149(5):1027-38 |
| 2) | Kenna MA, et al. (1996) Yeast N1e3p/Nup170p is required for normal stoichiometry of FG nucleoporins within the nuclear pore complex. Mol Cell Biol 16(5):2025-36 |
| 3) | Rout MP, et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51 |
| 4) | Aitchison JD, et al. (1995) Two novel related yeast nucleoporins Nup170p and Nup157p: complementation with the vertebrate homologue Nup155p and functional interactions with the yeast nuclear pore-membrane protein Pom152p. J Cell Biol 131(5):1133-48 |
| 5) | Kerscher O, et al. (2001) Novel role for a Saccharomyces cerevisiae nucleoporin, Nup170p, in chromosome segregation. Genetics 157(4):1543-53 |
| 6) | Makio T, et al. (2009) The nucleoporins Nup170p and Nup157p are essential for nuclear pore complex assembly. J Cell Biol 185(3):459-73 |
| 7) | Fabre E and Hurt E (1997) Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking. Annu Rev Genet 31:277-313 |
| 8) | Wente SR, et al. (1997) "The nucleus and nucleocytoplasmic transport in Saccharomyces cerevisiae." Pp. 471-546 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Cell Cycle and Cell Biology, edited by Pringle JR, Broach JR and Jones EW. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
| 9) | Pemberton LF, et al. (1998) Transport routes through the nuclear pore complex. Curr Opin Cell Biol 10(3):392-9 |
| 10) | Izaurralde E and Adam S (1998) Transport of macromolecules between the nucleus and the cytoplasm. RNA 4(4):351-64 |
| 11) | Hinshaw JE (1994) Architecture of the nuclear pore complex and its involvement in nucleocytoplasmic transport. Biochem Pharmacol 47(1):15-20 |
| 12) | Pante N and Aebi U (1996) Molecular dissection of the nuclear pore complex. Crit Rev Biochem Mol Biol 31(2):153-99 |
| 13) | Davis LI (1995) The nuclear pore complex. Annu Rev Biochem 64:865-96 |
| 14) | Pante N and Aebi U (1994) Toward the molecular details of the nuclear pore complex. J Struct Biol 113(3):179-89 |
| 15) | Rout MP and Blobel G (1993) Isolation of the yeast nuclear pore complex. J Cell Biol 123(4):771-83 |
| 16) | Yang Q, et al. (1998) Three-dimensional architecture of the isolated yeast nuclear pore complex: functional and evolutionary implications. Mol Cell 1(2):223-34 |
| 17) | Doye V and Hurt E (1997) From nucleoporins to nuclear pore complexes. Curr Opin Cell Biol 9(3):401-11 |
| 18) | Doye V and Hurt EC (1995) Genetic approaches to nuclear pore structure and function. Trends Genet 11(6):235-41 |
| 19) | Newmeyer DD (1993) The nuclear pore complex and nucleocytoplasmic transport. Curr Opin Cell Biol 5(3):395-407 |
| 20) | Nehrbass U, et al. (1996) The yeast nucleoporin Nup188p interacts genetically and physically with the core structures of the nuclear pore complex. J Cell Biol 133(6):1153-62 |
| 21) | Marelli M, et al. (1998) Specific binding of the karyopherin Kap121p to a subunit of the nuclear pore complex containing Nup53p, Nup59p, and Nup170p. J Cell Biol 143(7):1813-30 |
| 22) | Tcheperegine SE, et al. (1999) Topology and functional domains of the yeast pore membrane protein Pom152p. J Biol Chem 274(8):5252-8 |
