PRX1/YBL064C Summary

PRX1 BASIC INFORMATION

Standard Name	PRX1 1
Systematic Name	YBL064C
Feature Type	ORF, Verified
Description	Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated (1, 2, 3, 4)
Name Description	PeroxiRedoXin 1

GO Annotations	All PRX1 GO evidence and references
	View Computational GO annotations for PRX1
Molecular Function
Manually curated	thioredoxin peroxidase activity (IDA, IMP, ISS)
Biological Process
Manually curated	cell redox homeostasis (IDA, IMP) response to cadmium ion (IMP) response to oxidative stress (IGI)
Cellular Component
Manually curated	mitochondrion (IDA, ISS)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All PRX1 Phenotype details and references
Classical genetics
null	glutathione disulfide accumulation: increased metal resistance: decreased metal resistance: normal oxidative stress resistance: decreased thermotolerance: decreased
overexpression	metal resistance: increased oxidative stress resistance: increased
Large-scale survey
null	viable

Interactions	PRX1 All interactions details and references
	12 total interaction(s) for 12 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 6 Reconstituted Complex: 2

Sequence Information

ChrII:101158 to 100373 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..786	101158..100373	2004-07-16	1997-01-28

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000160

PRX1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PRX1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PRX1]

1)	Pedrajas JR, et al. (2000) Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity. J Biol Chem 275(21):16296-301
2)	Grant CM (2001) Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions. Mol Microbiol 39(3):533-41
3)	Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906
4)	Greetham D and Grant CM (2009) Antioxidant activity of the yeast mitochondrial one-Cys peroxiredoxin is dependent on thioredoxin reductase and glutathione in vivo. Mol Cell Biol 29(11):3229-40

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