Standard Name	SKT5
Systematic Name	YBL061C
Alias	CAL2 , CHS4 , CSD4
Feature Type	ORF, Verified
Description	Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication (1, 2, 3, 4, 5)

Chromosomal Location	ChrII:107406 to 105316 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SKT5
Molecular Function
Manually curated	enzyme activator activity (IMP)
Biological Process
Manually curated	fungal-type cell wall chitin biosynthetic process (IMP)
Cellular Component
Manually curated	cellular bud neck (IDA) colocalizes_with cellular bud neck septin ring (IDA) incipient cellular bud site (IDA)

Classical genetics
reduction of function	chitin deposition: decreased osmotic stress resistance: decreased resistance to Calcofluor white: decreased resistance to Calcofluor White: decreased
Large-scale survey
null	auxotrophy chitin deposition: decreased competitive fitness: decreased resistance to cycloheximide: decreased resistance to Calcofluor White: increased resistance to caspofungin: decreased resistance to caffeine: decreased stress resistance: decreased toxin resistance: increased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	284 total interaction(s) for 160 unique genes/features.
Physical Interactions	Affinity Capture-MS: 17 Biochemical Activity: 8 Two-hybrid: 8
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 2 Dosage Rescue: 3 Negative Genetic: 121 Positive Genetic: 4 Synthetic Growth Defect: 44 Synthetic Lethality: 72 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:107406 to 105316 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2091 107406..105316 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000157