SHP1/YBL058W Summary Help

Standard Name SHP1 1
Systematic Name YBL058W
Alias UBX1 2
Feature Type ORF, Verified
Description UBX (ubiquitin regulatory X) domain-containing protein; regulates Glc7p phosphatase activity; shp1 mutants are impaired in growth and mitotic progression; functions in growth and mitotic progression require Cdc48p binding; mitotic phenotype is caused by reduced Glc7p activity; interacts with ubiquitylated proteins, required for degradation of a ubiquitylated model substrate (1, 2, 3, 4)
Name Description Suppressor of High-copy PP1 1
Chromosomal Location
ChrII:111437 to 112708 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SHP1 GO evidence and references
  View Computational GO annotations for SHP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
Resources
379 total interaction(s) for 290 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 38
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 11
  • Biochemical Activity: 3
  • Co-purification: 2
  • PCA: 1
  • Reconstituted Complex: 8
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 6
  • Negative Genetic: 237
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 3
  • Positive Genetic: 23
  • Synthetic Growth Defect: 10
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 15
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 423
Molecular Weight (Da) 46,987
Isoelectric Point (pI) 4.72
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:111437 to 112708 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1272 111437..112708 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000154
References cited on this page View Complete Literature Guide for SHP1
1) Zhang S, et al.  (1995) The Saccharomyces SHP1 gene, which encodes a regulator of phosphoprotein phosphatase 1 with differential effects on glycogen metabolism, meiotic differentiation, and mitotic cell cycle progression. Mol Cell Biol 15(4):2037-50
2) Schuberth C, et al.  (2004) Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation. EMBO Rep 5(8):818-24
3) Tong AH, et al.  (2004) Global mapping of the yeast genetic interaction network. Science 303(5659):808-13
4) Bohm S and Buchberger A  (2013) The budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7). PLoS One 8(2):e56486