Standard Name	SHP1
Systematic Name	YBL058W
Alias	UBX1 1
Feature Type	ORF, Verified
Description	UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate (1, 2, 3)
Name Description	Suppressor of High-copy PP1 2

Chromosomal Location	ChrII:111437 to 112708 | ORF Map | GBrowse

	View Computational GO annotations for SHP1
Molecular Function
Manually curated	protein phosphatase type 1 regulator activity (IMP)
Biological Process
Manually curated	ascospore formation (IMP) autophagic vacuole assembly (IMP) ER-associated protein catabolic process (IMP) glycogen metabolic process (IMP) piecemeal microautophagy of nucleus (IMP) proteasomal ubiquitin-dependent protein catabolic process (IMP) sister chromatid biorientation (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Regulatory modules	predicted: stressResponse (511)

Classical genetics
null	autophagy: absent chromosome/plasmid maintenance: abnormal colony sectoring: increased ionic stress resistance: decreased metal resistance: decreased oxidative stress resistance: decreased Ptr2p-GFP distribution: abnormal resistance to FK506: decreased resistance to sirolimus: decreased resistance to tunicamycin: decreased resistance to Calcofluor White: decreased
Large-scale survey
null	acid pH resistance: decreased alkaline pH resistance: decreased auxotrophy bud morphology: abnormal cell cycle progression in G1 phase: decreased duration cell size: increased competitive fitness: decreased endocytosis: decreased fermentative growth: decreased rate freeze-thaw resistance: decreased heat sensitivity: increased metal resistance: decreased nutrient utilization: decreased resistance to sulfanilamide: decreased resistance to oleate: decreased resistance to cyclosporin A: decreased resistance to cadmium dichloride: decreased resistance to mycophenolic acid: decreased resistance to camptothecin: decreased resistance to hydroxyurea: decreased resistance to caffeine: decreased resistance to sirolimus: decreased resistance to tunicamycin: decreased resistance to acetic acid: decreased resistance to pyrrolidine dithiocarbamate: decreased resistance to pentachlorophenol: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to boric acid: decreased resistance to chloroquine: decreased resistance to citric acid: decreased resistance to L-1,4-dithiothreitol: decreased resistance to calcium dichloride: decreased resistance to cycloheximide: decreased resistance to ethanol: decreased resistance to sorbate: decreased resistance to doxorubicin: decreased respiratory growth: decreased rate small molecule transport: decreased sporulation: decreased sporulation: absent telomere length: decreased toxin resistance: increased toxin resistance: decreased utilization of iron source: decreased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	343 total interaction(s) for 269 unique genes/features.
Physical Interactions	Affinity Capture-MS: 34 Affinity Capture-RNA: 2 Affinity Capture-Western: 12 Biochemical Activity: 3 Co-purification: 2 PCA: 1 Reconstituted Complex: 6 Two-hybrid: 6
Genetic Interactions	Dosage Growth Defect: 2 Dosage Rescue: 6 Negative Genetic: 209 Phenotypic Enhancement: 3 Phenotypic Suppression: 3 Positive Genetic: 22 Synthetic Growth Defect: 9 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 15 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:111437 to 112708 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1272 111437..112708 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000154