Standard Name	PTC3 1
Systematic Name	YBL056W
Feature Type	ORF, Verified
Description	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6)
Name Description	Phosphatase Two C 1

Chromosomal Location	ChrII:113762 to 115168 | ORF Map | GBrowse

	View Computational GO annotations for PTC3
Molecular Function
Manually curated	protein serine/threonine phosphatase activity (IDA)
Biological Process
Manually curated	inactivation of MAPK activity involved in osmosensory signaling pathway (IGI) protein dephosphorylation (IDA) regulation of cyclin-dependent protein serine/threonine kinase activity (IMP, IPI)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Regulatory modules	predicted: stressResponse (529, 523, 367)

Classical genetics
null	toxin resistance: increased
overexpression	ionic stress resistance: increased
Large-scale survey
null	competitive fitness: decreased lifespan: increased starvation resistance: decreased stress resistance: decreased viable
overexpression	resistance to sirolimus: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	64 total interaction(s) for 45 unique genes/features.
Physical Interactions	Affinity Capture-MS: 28 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 PCA: 2 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 6 Negative Genetic: 6 Phenotypic Enhancement: 1 Positive Genetic: 6 Synthetic Growth Defect: 7 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:113762 to 115168 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1407 113762..115168 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000152