Standard Name	PSY4 1
Systematic Name	YBL046W
Feature Type	ORF, Verified
Description	Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2 (1, 2, 3, 4)
Name Description	Platinum SensitivitY 1

Chromosomal Location	ChrII:132424 to 133749 | ORF Map | GBrowse

	View Computational GO annotations for PSY4
Molecular Function
Manually curated	protein phosphatase regulator activity (IMP, IPI)
Biological Process
Manually curated	negative regulation of DNA damage checkpoint (IMP) protein dephosphorylation (IPI)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)
High-throughput	nucleus (IDA)

Classical genetics
null	resistance to cisplatin: decreased viable
Large-scale survey
null	glycogen accumulation: increased competitive fitness: increased resistance to bleomycin: decreased resistance to cycloheximide: decreased resistance to cycloheximide: increased resistance to sirolimus: increased resistance to camptothecin: decreased resistance to fenpropimorph: decreased resistance to dimethyl sulfoxide: decreased resistance to fluconazole: decreased respiratory growth: absent stress resistance: decreased transposable element transposition: decreased vegetative growth: decreased rate vegetative growth: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	75 total interaction(s) for 34 unique genes/features.
Physical Interactions	Affinity Capture-MS: 42 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Two-hybrid: 5
Genetic Interactions	Negative Genetic: 9 Phenotypic Suppression: 7 Positive Genetic: 4 Synthetic Growth Defect: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:132424 to 133749 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1326 132424..133749 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000142