Standard Name	ERD2 1, 2
Systematic Name	YBL040C
Feature Type	ORF, Verified
Description	HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins (1, 2, 3, 4)
Name Description	Endoplasmic reticulum Retention Defective 5

Chromosomal Location	ChrII:142868 to 142112 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for ERD2
Molecular Function
Manually curated	HDEL sequence binding (IGI, IMP, IPI)
Biological Process
Manually curated	ER to Golgi vesicle-mediated transport (IMP) protein retention in ER lumen (IGI)
Cellular Component
Manually curated	integral to endoplasmic reticulum membrane (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	inviable
repressible	Golgi morphology: abnormal CPY transport: abnormal
unspecified	protein secretion: abnormal
Large-scale survey
conditional	heat sensitivity: increased
null	inviable
repressible	protein transport: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	23 total interaction(s) for 20 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 PCA: 8
Genetic Interactions	Dosage Rescue: 5 Negative Genetic: 6 Synthetic Growth Defect: 1 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:142868 to 142112 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..22 142868..142847 2011-02-03 1997-01-28 Intron 23..119 142846..142750 2011-02-03 1997-01-28 CDS 120..757 142749..142112 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (23 - 119)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000136