STU1/YBL034C Summary Help

Standard Name STU1
Systematic Name YBL034C
Feature Type ORF, Verified
Description Component of the mitotic spindle; binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles (1, 2)
Name Description Suppressor of TUb2 mutation
Chromosomal Location
ChrII:158389 to 153848 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All STU1 GO evidence and references
  View Computational GO annotations for STU1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Large-scale survey
conditional
null
overexpression
Resources
195 total interaction(s) for 145 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 4
  • Co-localization: 4
  • Co-purification: 2
  • PCA: 1
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Rescue: 5
  • Negative Genetic: 86
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 5
  • Positive Genetic: 1
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 61
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,513
Molecular Weight (Da) 174,176
Isoelectric Point (pI) 6.25
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:158389 to 153848 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4542 158389..153848 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000130
References cited on this page View Complete Literature Guide for STU1
1) Pasqualone D and Huffaker TC  (1994) STU1, a suppressor of a beta-tubulin mutation, encodes a novel and essential component of the yeast mitotic spindle. J Cell Biol 127(6 Pt 2):1973-84
2) Yin H, et al.  (2002) Stu1p is physically associated with beta-tubulin and is required for structural integrity of the mitotic spindle. Mol Biol Cell 13(6):1881-92