SHE1/YBL031W Summary Help

Standard Name SHE1 1
Systematic Name YBL031W
Feature Type ORF, Verified
Description Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function (1, 2, 3, 4, 5)
Name Description Sensitivity to High Expression 1
Chromosomal Location
ChrII:161699 to 162715 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SHE1 GO evidence and references
  View Computational GO annotations for SHE1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
85 total interaction(s) for 68 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Two-hybrid: 6

Genetic Interactions
  • Negative Genetic: 54
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 9
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 338
Molecular Weight (Da) 38,015
Isoelectric Point (pI) 11.19
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:161699 to 162715 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1017 161699..162715 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000127
References cited on this page View Complete Literature Guide for SHE1
1) Espinet C, et al.  (1995) An efficient method to isolate yeast genes causing overexpression-mediated growth arrest. Yeast 11(1):25-32
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Shang C, et al.  (2003) Kinetochore protein interactions and their regulation by the Aurora kinase Ipl1p. Mol Biol Cell 14(8):3342-55
4) Wong J, et al.  (2007) A Protein Interaction Map of the Mitotic Spindle. Mol Biol Cell 18(10):3800-3809
5) Bergman ZJ, et al.  (2012) Constitutive dynein activity in She1 mutants reveals differences in microtubule attachment at the yeast spindle pole body. Mol Biol Cell 23(12):2319-26