HAP3/YBL021C Summary

HAP3 BASIC INFORMATION

Standard Name	HAP3
Systematic Name	YBL021C
Feature Type	ORF, Verified
Description	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding (1, 2)
Name Description	Heme Activator Protein 2

GO Annotations	All HAP3 GO evidence and references
	View Computational GO annotations for HAP3
Molecular Function
Manually curated	transcription activator activity (TAS)
Biological Process
Manually curated	regulation of carbohydrate metabolic process (TAS) transcription (TAS)
Cellular Component
Manually curated	CCAAT-binding factor complex (TAS) nucleus (IC)

Regulatory Role
Binding motifs	HAP3 Transcription Factor Binding Sites and References
	CCAAT

Mutant Phenotype	All HAP3 Phenotype details and references
Classical genetics
null	GDH3 accumulation: decreased
reduction of function	mitochondrial rho- mutation frequency: increased cytochromes accumulation: decreased utilization of carbon source: decreased
Large-scale survey
null	resistance to rapamycin: increased resistance to wortmannin: normal respiratory growth: decreased rate respiratory growth: absent viable

Interactions	HAP3 All interactions details and references
	20 total interaction(s) for 9 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Co-purification: 1 Reconstituted Complex: 8 Two-hybrid: 2
Genetic Interactions	Synthetic Lethality: 1 Synthetic Rescue: 1

Sequence Information

ChrII:182097 to 181663 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..435	182097..181663	2004-07-16	1997-01-28

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000117

HAP3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for HAP3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HAP3]

1)	Xing Y, et al. (1993) Mutations in yeast HAP2/HAP3 define a hybrid CCAAT box binding domain. EMBO J 12(12):4647-55
2)	Hahn S, et al. (1988) The HAP3 regulatory locus of Saccharomyces cerevisiae encodes divergent overlapping transcripts. Mol Cell Biol 8(2):655-63

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