HAP3/YBL021C Summary Help

Standard Name HAP3 1
Systematic Name YBL021C
Feature Type ORF, Verified
Description Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding (1, 2)
Name Description Heme Activator Protein 1
Chromosomal Location
ChrII:182094 to 181660 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All HAP3 GO evidence and references
  View Computational GO annotations for HAP3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
repressible
Resources
191 total interaction(s) for 135 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 1
  • Co-purification: 2
  • Reconstituted Complex: 8
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 150
  • Positive Genetic: 18
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 144
Molecular Weight (Da) 16,154
Isoelectric Point (pI) 4.6
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:182094 to 181660 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..435 182094..181660 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000117
References cited on this page View Complete Literature Guide for HAP3
1) Hahn S, et al.  (1988) The HAP3 regulatory locus of Saccharomyces cerevisiae encodes divergent overlapping transcripts. Mol Cell Biol 8(2):655-63
2) Xing Y, et al.  (1993) Mutations in yeast HAP2/HAP3 define a hybrid CCAAT box binding domain. EMBO J 12(12):4647-55
3) McNabb DS, et al.  (1995) Cloning of yeast HAP5: a novel subunit of a heterotrimeric complex required for CCAAT binding. Genes Dev 9(1):47-58