ALK2/YBL009W Summary Help

Standard Name ALK2 1
Systematic Name YBL009W
Feature Type ORF, Verified
Description Protein kinase; along with its paralog, ALK1, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of cell polarity factors in mitosis, proper localization of formins and polarity factors, and survival in cells that activate spindle assembly checkpoint; phosphorylated in response to DNA damage; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins (1, 2, 3)
Chromosomal Location
ChrII:207194 to 209224 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ALK2 GO evidence and references
  View Computational GO annotations for ALK2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 42 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
135 total interaction(s) for 133 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9

Genetic Interactions
  • Dosage Growth Defect: 11
  • Dosage Lethality: 3
  • Negative Genetic: 85
  • Phenotypic Suppression: 1
  • Positive Genetic: 25
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 676
Molecular Weight (Da) 76,372
Isoelectric Point (pI) 10.12
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:207194 to 209224 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2031 207194..209224 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000105
References cited on this page View Complete Literature Guide for ALK2
1) Nespoli A, et al.  (2006) Alk1 and Alk2 are two new cell cycle-regulated haspin-like proteins in budding yeast. Cell Cycle 5(13):1464-71
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Panigada D, et al.  (2013) Yeast haspin kinase regulates polarity cues necessary for mitotic spindle positioning and is required to tolerate mitotic arrest. Dev Cell 26(5):483-95