SLA1/YBL007C Summary Help

SLA1 BASIC INFORMATION

Standard Name SLA1 1
Systematic Name YBL007C
Feature Type ORF, Verified
Description Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains (2, 3, 4, 5)
Name Description Synthetic Lethal with ABP1 1
GO Annotations All SLA1 GO evidence and references
    View Computational GO annotations for SLA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All SLA1 Phenotype details and references
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
Interactions SLA1 All interactions details and references
314 total interaction(s) for 217 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 30
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 15
  • Biochemical Activity: 18
  • Far Western: 3
  • FRET: 2
  • PCA: 6
  • Protein-peptide: 1
  • Reconstituted Complex: 7
  • Two-hybrid: 136
Genetic Interactions
  • Dosage Lethality: 1
  • Phenotypic Enhancement: 33
  • Phenotypic Suppression: 5
  • Synthetic Growth Defect: 13
  • Synthetic Lethality: 42
  • Synthetic Rescue: 1
Sequence Information
ChrII:216369 to 212635 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3735 216369..212635 2004-07-16 1997-01-28
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000103

SLA1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for SLA1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SLA1]

1) Holtzman DA, et al.  (1993) Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae. J Cell Biol 122(3):635-44
2) Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85
3) Howard JP, et al.  (2002) Sla1p serves as the targeting signal recognition factor for NPFX(1,2)D-mediated endocytosis. J Cell Biol 157(2):315-26
4) Warren DT, et al.  (2002) Sla1p couples the yeast endocytic machinery to proteins regulating actin dynamics. J Cell Sci 115(Pt 8):1703-15
5) Gardiner FC, et al.  (2007) Nucleocytoplasmic trafficking is required for functioning of the adaptor protein sla1p in endocytosis. Traffic 8(4):347-58