Standard Name	CDC15 1 (see Nomenclature conflict Note)
Systematic Name	YAR019C
Alias	LYT1
Feature Type	ORF, Verified
Description	Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress (2, 3, 4)
Name Description	Cell Division Cycle 5

Chromosomal Location	ChrI:175135 to 172211 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 6 cM

	View Computational GO annotations for CDC15
Molecular Function
Manually curated	protein kinase activity (IDA)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	cytokinesis (IMP) meiotic anaphase II (IMP) protein phosphorylation (IDA) regulation of exit from mitosis (IMP)
High-throughput	protein phosphorylation (IDA)
Cellular Component
Manually curated	cellular bud neck (IDA) spindle pole body (IDA)
High-throughput	cytoplasm (IDA)

Regulatory modules	predicted: cellcycle (287)

Classical genetics
conditional	cell cycle progression: arrested cell cycle progression in late anaphase: arrested cell cycle progression in telophase: arrested cellular morphology: abnormal heat sensitivity: increased nuclear morphology: abnormal Kar9p distribution: abnormal Spc42p distribution: abnormal septum formation: abnormal spindle morphology: abnormal
Large-scale survey
null	inviable
reduction of function	competitive fitness: decreased
repressible	cell cycle progression in G2 phase: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	177 total interaction(s) for 101 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-RNA: 2 Affinity Capture-Western: 9 Biochemical Activity: 33 Co-localization: 6 Reconstituted Complex: 7 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 6 Dosage Rescue: 37 Phenotypic Enhancement: 11 Phenotypic Suppression: 12 Positive Genetic: 1 Synthetic Growth Defect: 14 Synthetic Lethality: 17 Synthetic Rescue: 13
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrI:175135 to 172211 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 6 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2925 175135..172211 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000072