KIN3/YAR018C Summary Help

Standard Name KIN3 1
Systematic Name YAR018C
Alias FUN52 2 , NPK1
Feature Type ORF, Verified
Description Nonessential serine/threonine protein kinase; possible role in DNA damage response; influences tolerance to high levels of ethanol (1, 3, 4)
Name Description protein KINase 1
Chromosomal Location
ChrI:171703 to 170396 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All KIN3 GO evidence and references
  View Computational GO annotations for KIN3
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Regulators 7 genes
Resources
Classical genetics
overexpression
Large-scale survey
null
overexpression
unspecified
Resources
252 total interaction(s) for 189 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-Western: 1
  • Biochemical Activity: 4
  • Reconstituted Complex: 1
  • Two-hybrid: 106

Genetic Interactions
  • Dosage Growth Defect: 6
  • Negative Genetic: 69
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 23
  • Positive Genetic: 23
  • Synthetic Growth Defect: 3
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 435
Molecular Weight (Da) 51,203
Isoelectric Point (pI) 8.65
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:171703 to 170396 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1308 171703..170396 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000071
References cited on this page View Complete Literature Guide for KIN3
1) Jones DG and Rosamond J  (1990) Isolation of a novel protein kinase-encoding gene from yeast by oligodeoxyribonucleotide probing. Gene 90(1):87-92
2) Barton AB, et al.  (1992) Cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the FUN52 gene, whose product has homology to protein kinases. Gene 117(1):137-40
3) Moura DJ, et al.  (2010) Kin3 protein, a NIMA-related kinase of Saccharomyces cerevisiae, is involved in DNA adduct damage response. Cell Cycle 9(11):2220-9
4) Pais TM, et al.  (2013) Comparative polygenic analysis of maximal ethanol accumulation capacity and tolerance to high ethanol levels of cell proliferation in yeast. PLoS Genet 9(6):e1003548