Standard Name	CNE1
Systematic Name	YAL058W
Alias	FUN48
Feature Type	ORF, Verified
Description	Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast (1, 2, 3, 4)
Name Description	CalNExin and calreticulin homolog

Chromosomal Location	ChrI:37464 to 38972 | ORF Map | GBrowse

	View Computational GO annotations for CNE1
Molecular Function
Manually curated	unfolded protein binding (IMP, ISS)
Biological Process
Manually curated	ER-associated protein catabolic process (IMP) protein folding (IMP)
Cellular Component
Manually curated	integral to endoplasmic reticulum membrane (IDA)

Classical genetics
null	resistance to mitoxantrone: increased resistance to DFD-VI-15: increased
Large-scale survey
null	auxotrophy competitive fitness: decreased resistance to fenpropimorph: decreased resistance to hygromycin B: decreased resistance to camptothecin: decreased resistance to hydroxyurea: increased resistance to fluconazole: decreased resistance to mycophenolic acid: decreased resistance to tunicamycin: decreased resistance to cycloheximide: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	192 total interaction(s) for 103 unique genes/features.
Physical Interactions	Affinity Capture-Western: 2 PCA: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 103 Phenotypic Enhancement: 50 Phenotypic Suppression: 10 Positive Genetic: 10 Synthetic Growth Defect: 14 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrI:37464 to 38972 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1509 37464..38972 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000054