Standard Name	PTA1
Systematic Name	YAL043C
Alias	FUN39
Feature Type	ORF, Verified
Description	Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII (1, 2, 3, 4, 5)
Name Description	Pre-Trna Accumulation 2

Chromosomal Location	ChrI:61052 to 58695 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PTA1
Molecular Function
Manually curated	contributes_to RNA binding (IC)
Biological Process
Manually curated	mRNA cleavage (IMP) mRNA polyadenylation (IMP) termination of RNA polymerase II transcription, exosome-dependent (IPI) termination of RNA polymerase II transcription, poly(A)-coupled (IPI) tRNA processing (IMP)
Cellular Component
Manually curated	mRNA cleavage and polyadenylation specificity factor complex (IDA, IPI) mRNA cleavage factor complex (IPI)

Classical genetics
conditional	mature 18S rRNA accumulation: decreased 3' extended forms of NAB2 mRNA accumulation: increased heat sensitivity: increased Ssu72p accumulation: decreased Rpo21p modification: increased
null	inviable
Large-scale survey
conditional	heat sensitivity: increased
null	inviable starvation resistance: decreased
reduction of function	competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	268 total interaction(s) for 113 unique genes/features.
Physical Interactions	Affinity Capture-MS: 157 Affinity Capture-RNA: 2 Affinity Capture-Western: 9 Biochemical Activity: 3 Co-purification: 1 Far Western: 1 Reconstituted Complex: 16 Two-hybrid: 5
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 2 Negative Genetic: 67 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrI:61052 to 58695 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2358 61052..58695 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000041