PTA1/YAL043C Summary Help

PTA1 BASIC INFORMATION

Standard Name PTA1
Systematic Name YAL043C
Alias FUN39
Feature Type ORF, Verified
Description Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII (1, 2, 3, 4, 5)
Name Description Pre-Trna Accumulation 2
GO Annotations All PTA1 GO evidence and references
    View Computational GO annotations for PTA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All PTA1 Phenotype details and references
Classical genetics
conditional
null
Large-scale survey
conditional
null
Interactions PTA1 All interactions details and references
220 total interaction(s) for 71 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 155
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 8
  • Biochemical Activity: 3
  • Co-purification: 1
  • Far Western: 1
  • Reconstituted Complex: 14
  • Two-hybrid: 4
Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 27
  • Synthetic Rescue: 1
Sequence Information
ChrI:61053 to 58696 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2358 61053..58696 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000041

PTA1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for PTA1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PTA1]

1) Preker PJ, et al.  (1997) A multisubunit 3' end processing factor from yeast containing poly(A) polymerase and homologues of the subunits of mammalian cleavage and polyadenylation specificity factor. EMBO J 16(15):4727-37
2) O'Connor JP and Peebles CL  (1992) PTA1, an essential gene of Saccharomyces cerevisiae affecting pre-tRNA processing. Mol Cell Biol 12(9):3843-56
3) Zhao J, et al.  (1999) Pta1, a component of yeast CF II, is required for both cleavage and poly(A) addition of mRNA precursor. Mol Cell Biol 19(11):7733-40
4) Rodriguez CR, et al.  (2000) Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II. Mol Cell Biol 20(1):104-12
5) Nedea E, et al.  (2003) Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. J Biol Chem 278(35):33000-10