CDC24/YAL041W Summary

CDC24 BASIC INFORMATION

Standard Name	CDC24
Systematic Name	YAL041W
Alias	CLS4
Feature Type	ORF, Verified
Description	Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing (1, 2)
Name Description	Cell Division Cycle 3

GO Annotations	All CDC24 GO evidence and references
	View Computational GO annotations for CDC24
Molecular Function
Manually curated	Rho guanyl-nucleotide exchange factor activity (TAS)
Biological Process
Manually curated	budding cell apical bud growth (IPI) budding cell isotropic bud growth (IPI) cellular morphogenesis during conjugation with cellular fusion (IMP) chitin localization (IMP) establishment of cell polarity (TAS) invasive growth in response to glucose limitation (IPI) pheromone-dependent signal transduction involved in conjugation with cellular fusion (IGI, IPI, TAS) pseudohyphal growth (IPI) regulation of exit from mitosis (IMP) small GTPase mediated signal transduction (TAS)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) cytoplasm (IDA) incipient cellular bud site (IDA) mating projection tip (IDA) nucleus (IDA)

Mutant Phenotype	All CDC24 Phenotype details and references
Classical genetics
conditional	budding: absent cell cycle progression: arrested cellular morphology: abnormal heat sensitivity: increased nuclear morphology: abnormal shmoo formation: abnormal
unspecified	mating efficiency: decreased
Large-scale survey
null	inviable

Interactions	CDC24 All interactions details and references
	120 total interaction(s) for 46 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-RNA: 1 Affinity Capture-Western: 18 Biochemical Activity: 1 Co-crystal Structure: 1 Co-fractionation: 2 PCA: 1 Protein-peptide: 1 Reconstituted Complex: 11 Two-hybrid: 28
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 22 Phenotypic Enhancement: 2 Synthetic Growth Defect: 3 Synthetic Lethality: 12 Synthetic Rescue: 2

Sequence Information

ChrI:62841 to 65405 | |

Genetic position: -56 cM

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2565	62841..65405	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000039

CDC24 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for CDC24

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CDC24]

1)	Chenevert J, et al. (1994) Identification of genes required for normal pheromone-induced cell polarization in Saccharomyces cerevisiae. Genetics 136(4):1287-96
2)	Sloat BF and Pringle JR (1978) A mutant of yeast defective in cellular morphogenesis. Science 200(4346):1171-3
3)	Hartwell LH, et al. (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9

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