CDC24/YAL041W Summary Help

Standard Name CDC24 1
Systematic Name YAL041W
Alias CLS4 2
Feature Type ORF, Verified
Description Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress (3, 4, 5)
Name Description Cell Division Cycle 6
Chromosomal Location
ChrI:62840 to 65404 | ORF Map | GBrowse
Gbrowse
Genetic position: -56 cM
Gene Ontology Annotations All CDC24 GO evidence and references
  View Computational GO annotations for CDC24
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
conditional
unspecified
Large-scale survey
conditional
null
reduction of function
Resources
282 total interaction(s) for 169 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 26
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 21
  • Biochemical Activity: 2
  • Co-crystal Structure: 1
  • Co-fractionation: 2
  • PCA: 2
  • Protein-peptide: 1
  • Reconstituted Complex: 11
  • Two-hybrid: 35

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 25
  • Negative Genetic: 105
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 5
  • Positive Genetic: 9
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 20
  • Synthetic Rescue: 10

Resources
Expression Summary
histogram
Resources
Length (a.a.) 854
Molecular Weight (Da) 96,939
Isoelectric Point (pI) 8.69
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:62840 to 65404 | ORF Map | GBrowse
SGD ORF map
Genetic position: -56 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2565 62840..65404 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000039
References cited on this page View Complete Literature Guide for CDC24
1) Hartwell LH, et al.  (1973) Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants. Genetics 74(2):267-286
2) Ohya Y, et al.  (1986) Calcium-sensitive cls4 mutant of Saccharomyces cerevisiae with a defect in bud formation. J Bacteriol 165(1):28-33
3) Chenevert J, et al.  (1994) Identification of genes required for normal pheromone-induced cell polarization in Saccharomyces cerevisiae. Genetics 136(4):1287-96
4) Sloat BF and Pringle JR  (1978) A mutant of yeast defective in cellular morphogenesis. Science 200(4346):1171-3
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
6) Hartwell LH, et al.  (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9