Standard Name	CYC3
Systematic Name	YAL039C
Feature Type	ORF, Verified
Description	Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS) (1, 2)
Name Description	CYtochrome C
Gene Product Alias	CCHL 3 , cytochrome c heme lyase 3

Chromosomal Location	ChrI:69525 to 68716 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -47 cM

	View Computational GO annotations for CYC3
Molecular Function
Manually curated	holocytochrome-c synthase activity (IDA)
Biological Process
Manually curated	cytochrome c-heme linkage (IDA)
Cellular Component
Manually curated	mitochondrial intermembrane space (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	apoptosis: decreased chronological lifespan: decreased necrotic cell death: decreased resistance to dihydromotuporamine C: increased
Large-scale survey
null	glycogen accumulation: decreased proton accumulation: decreased competitive fitness: decreased dessication resistance: decreased resistance to ethanol: decreased resistance to methyl methanesulfonate: decreased respiratory growth: absent respiratory growth: decreased rate vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	27 total interaction(s) for 24 unique genes/features.
Physical Interactions	Biochemical Activity: 4 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 2 Dosage Rescue: 2 Negative Genetic: 9 Phenotypic Enhancement: 1 Positive Genetic: 2 Synthetic Growth Defect: 4 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrI:69525 to 68716 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -47 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..810 69525..68716 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000037