MTW1/YAL034W-A Summary Help

Standard Name MTW1 1
Systematic Name YAL034W-A
Alias DSN3 , NSL2
Feature Type ORF, Verified
Description Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p (MIND) (2)
Name Description Mis TWelve-like 1
Chromosomal Location
ChrI:79718 to 80587 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MTW1 GO evidence and references
  View Computational GO annotations for MTW1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
conditional
Large-scale survey
conditional
null
reduction of function
repressible
unspecified
Resources
169 total interaction(s) for 104 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 38
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 23
  • Biochemical Activity: 9
  • Co-crystal Structure: 1
  • Co-fractionation: 1
  • Co-localization: 4
  • PCA: 2
  • Reconstituted Complex: 11
  • Two-hybrid: 14

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 49
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 2
  • Positive Genetic: 7
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 289
Molecular Weight (Da) 33,243
Isoelectric Point (pI) 4.96
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:79718 to 80587 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..870 79718..80587 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000032
References cited on this page View Complete Literature Guide for MTW1
1) Goshima G and Yanagida M  (2000) Establishing biorientation occurs with precocious separation of the sister kinetochores, but not the arms, in the early spindle of budding yeast. Cell 100(6):619-33
2) De Wulf P, et al.  (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21