MTW1/YAL034W-A Summary

MTW1 BASIC INFORMATION

Standard Name	MTW1
Systematic Name	YAL034W-A
Alias	DSN3 , NSL2
Feature Type	ORF, Verified
Description	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly (1)
Name Description	Mis TWelve-like 2

GO Annotations	All MTW1 GO evidence and references
	View Computational GO annotations for MTW1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chromosome segregation (IDA) protein localization to kinetochore (IMP)
Cellular Component
Manually curated	nuclear MIS12/MIND type complex (IDA) spindle pole (IDA)

Mutant Phenotype	All MTW1 Phenotype details and references
Large-scale survey
null	inviable

Interactions	MTW1 All interactions details and references
	83 total interaction(s) for 39 unique genes/features.
Physical Interactions	Affinity Capture-MS: 28 Affinity Capture-Western: 20 Biochemical Activity: 9 Co-fractionation: 1 Co-localization: 4 Two-hybrid: 14
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Synthetic Lethality: 2

Sequence Information

ChrI:79719 to 80588 | |

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..870	79719..80588	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000032

MTW1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MTW1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MTW1]

1)	De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21
2)	Goshima G and Yanagida M (2000) Establishing biorientation occurs with precocious separation of the sister kinetochores, but not the arms, in the early spindle of budding yeast. Cell 100(6):619-33

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.