POP5/YAL033W Summary Help

Standard Name POP5 1
Systematic Name YAL033W
Alias FUN53 2
Feature Type ORF, Verified
Description Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs (1, 3, 4)
Name Description Processing Of Precursor RNAs
Chromosomal Location
ChrI:82706 to 83227 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All POP5 GO evidence and references
  View Computational GO annotations for POP5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
reduction of function
repressible
unspecified
Resources
45 total interaction(s) for 19 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 18
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 13
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 4

Genetic Interactions
  • Negative Genetic: 1
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 173
Molecular Weight (Da) 19,573
Isoelectric Point (pI) 7.83
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:82706 to 83227 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..522 82706..83227 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000031
References cited on this page View Complete Literature Guide for POP5
1) Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90
2) Harris SD, et al.  (1992) Molecular analysis of Saccharomyces cerevisiae chromosome I. On the number of genes and the identification of essential genes using temperature-sensitive-lethal mutations. J Mol Biol 225(1):53-65
3) Houser-Scott F, et al.  (2002) Interactions among the protein and RNA subunits of Saccharomyces cerevisiae nuclear RNase P. Proc Natl Acad Sci U S A 99(5):2684-9
4) Marvin MC, et al.  (2011) Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae. RNA 17(8):1441-50