CCR4/YAL021C Summary Help

CCR4 BASIC INFORMATION

Standard Name CCR4 1, 2
Systematic Name YAL021C
Alias FUN27 , NUT21
Feature Type ORF, Verified
Description Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening (3, 4, 5)
Name Description Carbon Catabolite Repression 1
GO Annotations All CCR4 GO evidence and references
    View Computational GO annotations for CCR4
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Mutant Phenotype All CCR4 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions CCR4 All interactions details and references
383 total interaction(s) for 221 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 53
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 37
  • Biochemical Activity: 1
  • Co-fractionation: 2
  • Co-purification: 5
  • PCA: 6
  • Reconstituted Complex: 1
  • Two-hybrid: 19
Genetic Interactions
  • Dosage Lethality: 3
  • Dosage Rescue: 8
  • Phenotypic Enhancement: 13
  • Phenotypic Suppression: 7
  • Synthetic Growth Defect: 105
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 105
  • Synthetic Rescue: 15
Sequence Information
ChrI:113360 to 110847 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -25 cM
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2514 113360..110847 2004-07-20 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000019

CCR4 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for CCR4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CCR4]

1) Denis CL  (1984) Identification of new genes involved in the regulation of yeast alcohol dehydrogenase II. Genetics 108(4):833-44
2) Denis, C.  (1989) Personal Communication, Mortimer Map Edition 10
3) Liu HY, et al.  (1998) The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively. EMBO J 17(4):1096-106
4) Denis CL and Malvar T  (1990) The CCR4 gene from Saccharomyces cerevisiae is required for both nonfermentative and spt-mediated gene expression. Genetics 124(2):283-91
5) Tucker M, et al.  (2001) The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Cell 104(3):377-86