Standard Name	ATS1
Systematic Name	YAL020C
Alias	FUN28 , KTI13 1 , 2
Feature Type	ORF, Verified
Description	Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle (3, 4, 5)
Name Description	Alpha Tubulin Suppressor 3

Chromosomal Location	ChrI:114615 to 113614 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	budding cell bud growth (IGI, IMP) microtubule cytoskeleton organization (IGI, IMP) microtubule-based process (IGI, ISS) tRNA wobble uridine modification (IMP)
Cellular Component
Manually curated	cytoplasm (IDA, IPI)

Classical genetics
conditional	heat sensitivity: increased resistance to caffeine: decreased
null	heat sensitivity: increased killer toxin resistance: increased resistance to caffeine: decreased toxin resistance: increased viable
overexpression	killer toxin resistance: decreased
unspecified	killer toxin resistance: increased
Large-scale survey
null	tRNA modification: abnormal acid pH resistance: decreased competitive fitness: decreased heat sensitivity: increased Fus-Mid-GFP distribution: abnormal resistance to sirolimus: decreased resistance to ethanol: decreased resistance to hygromycin B: decreased resistance to benzo[a]pyrene: decreased resistance to wortmannin: normal stress resistance: increased toxin resistance: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	123 total interaction(s) for 91 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-Western: 5 Biochemical Activity: 4 PCA: 1 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 1 Negative Genetic: 85 Phenotypic Suppression: 1 Positive Genetic: 1 Synthetic Growth Defect: 13 Synthetic Lethality: 4 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrI:114615 to 113614 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1002 114615..113614 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000018