FUN30/YAL019W Summary Help

Standard Name FUN30 1
Systematic Name YAL019W
Feature Type ORF, Verified
Description Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate (1, 2, 3, 4, 5, 6, 7, 8)
Name Description Function Unknown Now 9
Chromosomal Location
ChrI:114919 to 118314 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All FUN30 GO evidence and references
  View Computational GO annotations for FUN30
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
overexpression
Resources
124 total interaction(s) for 89 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 7
  • Biochemical Activity: 1
  • Far Western: 2
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 45
  • Phenotypic Enhancement: 25
  • Phenotypic Suppression: 3
  • Positive Genetic: 9
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,131
Molecular Weight (Da) 128,506
Isoelectric Point (pI) 5.13
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:114919 to 118314 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3396 114919..118314 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000017
References cited on this page View Complete Literature Guide for FUN30
1) Clark MW, et al.  (1992) Identification of a Saccharomyces cerevisiae homolog of the SNF2 transcriptional regulator in the DNA sequence of an 8.6 kb region in the LTE1-CYS1 interval on the left arm of chromosome I. Yeast 8(2):133-45
2) Ouspenski II, et al.  (1999) New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res 27(15):3001-8
3) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
4) Neves-Costa A, et al.  (2009) The SNF2-family member Fun30 promotes gene silencing in heterochromatic loci. PLoS One 4(12):e8111
5) Awad S, et al.  (2010) The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme. J Biol Chem 285(13):9477-84
6) Costelloe T, et al.  (2012) The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection. Nature 489(7417):581-4
7) Chen X, et al.  (2012) The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends. Nature 489(7417):576-80
8) Durand-Dubief M, et al.  (2012) SWI/SNF-Like Chromatin Remodeling Factor Fun30 Supports Point Centromere Function in S. cerevisiae. PLoS Genet 8(9):e1002974
9) Coleman KG, et al.  (1986) Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation and characterization of the CDC24 gene and adjacent regions of the chromosome. Mol Cell Biol 6(12):4516-25