PSK1/YAL017W Summary Help

Standard Name PSK1 1
Systematic Name YAL017W
Alias FUN31
Feature Type ORF, Verified
Description PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication (1, 2, 3)
Name Description Pas domain-containing Serine/threonine protein Kinase 1
Chromosomal Location
ChrI:120225 to 124295 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PSK1 GO evidence and references
  View Computational GO annotations for PSK1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
86 total interaction(s) for 77 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 23
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 18
  • Co-purification: 1
  • PCA: 1
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Growth Defect: 3
  • Dosage Rescue: 14
  • Negative Genetic: 14
  • Phenotypic Enhancement: 1
  • Positive Genetic: 4
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,356
Molecular Weight (Da) 152,332
Isoelectric Point (pI) 5.45
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:120225 to 124295 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4071 120225..124295 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000015
References cited on this page View Complete Literature Guide for PSK1
1) Rutter J, et al.  (2002) Coordinate regulation of sugar flux and translation by PAS kinase. Cell 111(1):17-28
2) Rutter J  (2002) Essay: Amersham Biosciences and Science Prize. PAS domains and metabolic status signaling. Science 298(5598):1567-8
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61