Standard Name	DEP1
Systematic Name	YAL013W
Alias	FUN54 1
Feature Type	ORF, Verified
Description	Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation (2, 3)
Name Description	Disability in regulation of Expression of genes involved in Phospholipid biosynthesis 2

Chromosomal Location	ChrI:129270 to 130487 | ORF Map | GBrowse
	Genetic position: 12 cM

	View Computational GO annotations for DEP1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	histone deacetylation (IMP) negative regulation of chromatin silencing at rDNA (IMP) negative regulation of chromatin silencing at silent mating-type cassette (IMP) negative regulation of chromatin silencing at telomere (IDA, IGI, IMP) negative regulation of inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter (IMP) negative regulation of phosphatidylcholine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter (IMP) negative regulation of phosphatidylserine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter (IMP) negative regulation of transcription from RNA polymerase II promoter (IMP) positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter (IMP) positive regulation of phosphatidylcholine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter (IMP) positive regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter (IMP) positive regulation of transcription from RNA polymerase II promoter in response to heat stress (IMP) regulation of DNA-dependent DNA replication initiation (IMP) regulation of transcription from RNA polymerase II promoter (IMP)
Cellular Component
Manually curated	Rpd3L complex (IDA)
High-throughput	Rpd3L complex (IDA) Rpd3L-Expanded complex (IDA)

Classical genetics
null	Histone H4 modification: increased resistance to cycloheximide: decreased silencing: increased
unspecified	INO1-lacZ mRNA accumulation: increased cell size: increased mating efficiency: decreased sporulation: decreased viability: decreased
Large-scale survey
null	acid pH resistance: decreased proton accumulation: increased glycogen accumulation: decreased inositol excretion: increased chitin deposition: decreased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased heat sensitivity: increased resistance to wortmannin: decreased resistance to sulfanilamide: decreased resistance to ethanol: decreased resistance to cycloheximide: decreased resistance to boric acid: decreased resistance to elesclomol-Cu: decreased resistance to sirolimus: increased resistance to calcium dichloride: decreased resistance to doxorubicin: decreased respiratory growth: decreased rate respiratory growth: absent sporulation: decreased stress resistance: decreased telomere length: decreased transposable element transposition: decreased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	704 total interaction(s) for 460 unique genes/features.
Physical Interactions	Affinity Capture-MS: 46 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 1 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 439 Phenotypic Suppression: 1 Positive Genetic: 99 Synthetic Growth Defect: 52 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 53 Synthetic Rescue: 8
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrI:129270 to 130487 | ORF Map | GBrowse
	Genetic position: 12 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1218 129270..130487 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000011