DEP1/YAL013W Summary Help

Standard Name DEP1 1
Systematic Name YAL013W
Alias FUN54 2
Feature Type ORF, Verified
Description Component of the Rpd3L histone deacetylase complex; required for diauxic shift-induced histone H2B deposition onto rDNA genes; transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation (1, 3, 4, 5)
Name Description Disability in regulation of Expression of genes involved in Phospholipid biosynthesis 1
Chromosomal Location
ChrI:129270 to 130487 | ORF Map | GBrowse
Gbrowse
Genetic position: 12 cM
Gene Ontology Annotations All DEP1 GO evidence and references
  View Computational GO annotations for DEP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 131 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
repressible
Resources
709 total interaction(s) for 460 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 46
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 441
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Positive Genetic: 100
  • Synthetic Growth Defect: 52
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 53
  • Synthetic Rescue: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 405
Molecular Weight (Da) 46,978
Isoelectric Point (pI) 4.32
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:129270 to 130487 | ORF Map | GBrowse
SGD ORF map
Genetic position: 12 cM
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1218 129270..130487 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000011
References cited on this page View Complete Literature Guide for DEP1
1) Lamping E, et al.  (1994) Isolation and characterization of a mutant of Saccharomyces cerevisiae with pleiotropic deficiencies in transcriptional activation and repression. Genetics 137(1):55-65
2) Clark MW, et al.  (1994) Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region. Yeast 10(4):535-41
3) Carrozza MJ, et al.  (2005) Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Biochim Biophys Acta 1731(2):77-87; discussion 75-6
4) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63
5) Johnson JM, et al.  (2013) Rpd3- and spt16-mediated nucleosome assembly and transcriptional regulation on yeast ribosomal DNA genes. Mol Cell Biol 33(14):2748-59