Standard Name	CYS3
Systematic Name	YAL012W
Alias	CYI1 , FUN35 , STR1 1
Feature Type	ORF, Verified
Description	Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress (2, 3, 4, 5)
Name Description	CYStathionine gamma-lyase

Chromosomal Location	ChrI:130799 to 131983 | ORF Map | GBrowse
	Genetic position: -16 cM

	View Computational GO annotations for CYS3
Molecular Function
Manually curated	cystathionine gamma-lyase activity (IDA, IMP)
Biological Process
Manually curated	cysteine biosynthetic process (IMP) cysteine biosynthetic process via cystathionine (IMP) transsulfuration (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	cysteine biosynthesis from homocysteine homocysteine and cysteine interconversion homocysteine degradation superpathway of sulfur amino acid biosynthesis threonine catabolism

Classical genetics
null	auxotrophy 3-mercaptohexan-1-ol accumulation: increased 4-mercapto-4-methylpentan-2-one excretion: decreased growth in exponential phase: decreased resistance to selenium(2+): decreased viable
Large-scale survey
null	alkaline pH resistance: decreased proton accumulation: decreased competitive fitness: decreased filamentous growth: decreased heat sensitivity: increased invasive growth: absent inviable metal resistance: decreased resistance to sodium selenide: decreased resistance to 4-chlorophenol: decreased resistance to sodium arsenite: decreased resistance to arsenite(3-): decreased resistance to CTBT: decreased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to PM02734: increased resistance to selenomethionine: increased resistance to dimethyl sulfoxide: decreased resistance to elesclomol-Cu: decreased resistance to chloroquine: decreased resistance to acrolein: decreased resistance to sorbate: decreased respiratory growth: absent starvation resistance: decreased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	187 total interaction(s) for 155 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 3 Co-crystal Structure: 1 PCA: 3 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 87 Phenotypic Enhancement: 20 Phenotypic Suppression: 37 Positive Genetic: 21 Synthetic Growth Defect: 3 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrI:130799 to 131983 | ORF Map | GBrowse
	Genetic position: -16 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1185 130799..131983 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000010