SWC3/YAL011W Summary Help

Standard Name SWC3 1
Systematic Name YAL011W
Alias SWC1
Feature Type ORF, Verified
Description Protein of unknown function; component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae (2, 3, 4)
Name Description SWr Complex
Chromosomal Location
ChrI:132199 to 134076 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SWC3 GO evidence and references
  View Computational GO annotations for SWC3
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
614 total interaction(s) for 323 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 43
  • Affinity Capture-Western: 7
  • Co-purification: 1
  • Two-hybrid: 21

Genetic Interactions
  • Negative Genetic: 305
  • Phenotypic Enhancement: 39
  • Phenotypic Suppression: 14
  • Positive Genetic: 45
  • Synthetic Growth Defect: 83
  • Synthetic Lethality: 55
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 625
Molecular Weight (Da) 72,514
Isoelectric Point (pI) 9.95
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:132199 to 134076 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1878 132199..134076 2011-02-03 2003-09-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000009
References cited on this page View Complete Literature Guide for SWC3
1) Schaft, D, et al.  (2002) personal communication
2) Wright R, et al.  (2003) Parallel analysis of tagged deletion mutants efficiently identifies genes involved in endoplasmic reticulum biogenesis. Yeast 20(10):881-92
3) Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76
4) Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8