Standard Name	SWC3 1 (see Nomenclature conflict Note)
Systematic Name	YAL011W
Alias	SWC1
Feature Type	ORF, Verified
Description	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae (2, 3, 4)
Name Description	SWr Complex

Chromosomal Location	ChrI:132199 to 134076 | ORF Map | GBrowse

	View Computational GO annotations for SWC3
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chromatin remodeling (IDA, IMP) endoplasmic reticulum organization (IMP) histone exchange (IPI)
High-throughput	chromatin remodeling (IGI)
Cellular Component
Manually curated	Swr1 complex (IDA)
High-throughput	mitochondrion (IDA) nucleus (IDA)

Classical genetics
null	chromosome/plasmid maintenance: abnormal endoplasmic reticulum morphology: abnormal
Large-scale survey
null	bud morphology: abnormal competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased metal resistance: decreased protein transport: abnormal resistance to hygromycin B: decreased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased resistance to sirolimus: decreased resistance to fenpropimorph: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to spermine: decreased resistance to bleomycin: decreased resistance to camptothecin: decreased resistance to caffeine: decreased resistance to fluconazole: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to mycophenolic acid: decreased resistance to tunicamycin: decreased resistance to sodium selenide: decreased resistance to dimethyl sulfoxide: decreased resistance to flubendazole: decreased resistance to wortmannin: normal sporulation efficiency: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	609 total interaction(s) for 321 unique genes/features.
Physical Interactions	Affinity Capture-MS: 41 Affinity Capture-Western: 7 Two-hybrid: 21
Genetic Interactions	Negative Genetic: 305 Phenotypic Enhancement: 38 Phenotypic Suppression: 14 Positive Genetic: 45 Synthetic Growth Defect: 82 Synthetic Lethality: 55 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrI:132199 to 134076 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1878 132199..134076 2011-02-03 2003-09-22
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000009