Standard Name	MDM10
Systematic Name	YAL010C
Alias	FUN37 1
Feature Type	ORF, Verified
Description	Subunit of both the ERMES complex that links the ER to mitochondria, and of the mitochondrial sorting and assembly machinery (SAM complex) that functions in import and assembly of outer membrane beta-barrel proteins (2, 3, 4)
Name Description	Mitochondrial Distribution and Morphology

Chromosomal Location	ChrI:135665 to 134184 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for MDM10
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	establishment of mitochondrion localization (IMP) mitochondrial outer membrane translocase complex assembly (IMP, IPI) mitochondrion organization (IMP) phospholipid transport (IGI) protein import into mitochondrial outer membrane (IMP)
Cellular Component
Manually curated	ERMES complex (IPI) mitochondrial sorting and assembly machinery complex (IPI)
High-throughput	mitochondrial outer membrane (IDA)

Classical genetics
conditional	mitochondrial morphology: abnormal
null	tellurium atom accumulation: decreased phosphatidylethanolamine accumulation: decreased cardiolipin accumulation: decreased heat sensitivity: increased mitochondrial morphology: abnormal respiratory growth: absent viability: decreased
overexpression	vegetative growth: decreased rate
Large-scale survey
null	cell size: decreased competitive fitness: increased dessication resistance: decreased endocytosis: decreased filamentous growth: decreased haploinsufficient heat sensitivity: increased invasive growth: absent metal resistance: decreased mitochondrial morphology: abnormal resistance to oleate: decreased resistance to ethanol: decreased resistance to trichothecene: increased resistance to propan-1-ol: decreased resistance to 2,4-dichlorophenol: decreased respiratory growth: absent telomere length: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	289 total interaction(s) for 189 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 1 Affinity Capture-Western: 31 PCA: 1
Genetic Interactions	Dosage Growth Defect: 2 Dosage Rescue: 3 Negative Genetic: 176 Phenotypic Enhancement: 4 Phenotypic Suppression: 2 Positive Genetic: 33 Synthetic Growth Defect: 23 Synthetic Lethality: 5 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrI:135665 to 134184 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1482 135665..134184 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000008