MDM10/YAL010C Summary

MDM10 BASIC INFORMATION

Standard Name	MDM10
Systematic Name	YAL010C
Alias	FUN37 1
Feature Type	ORF, Verified
Description	Subunit of both the ERMES complex that links the ER to mitochondria, and of the mitochondrial sorting and assembly machinery (SAM complex) that functions in import and assembly of outer membrane beta-barrel proteins (2, 3, 4)
Name Description	Mitochondrial Distribution and Morphology

GO Annotations	All MDM10 GO evidence and references
	View Computational GO annotations for MDM10
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	mitochondrial genome maintenance (TAS) mitochondrion inheritance (TAS) mitochondrion organization (TAS) phospholipid transport (IGI) protein complex assembly (IMP) protein import into mitochondrial outer membrane (IMP)
Cellular Component
Manually curated	ERMES complex (IPI) mitochondrial sorting and assembly machinery complex (IPI)
High-throughput	mitochondrial outer membrane (IDA)

Mutant Phenotype	All MDM10 Phenotype details and references
Classical genetics
null	phosphatidylethanolamines accumulation: decreased cardiolipin accumulation: decreased heat sensitivity: increased respiratory growth: absent
Large-scale survey
null	filamentous growth: decreased heat sensitivity: increased invasive growth: absent mitochondrial morphology: abnormal resistance to oleate: decreased resistance to ethanol: decreased resistance to propan-1-ol: decreased respiratory growth: absent telomere length: increased viable

Interactions	MDM10 All interactions details and references
	34 total interaction(s) for 23 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-Western: 10 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 2 Phenotypic Suppression: 2 Synthetic Growth Defect: 9 Synthetic Lethality: 5

Sequence Information

ChrI:135667 to 134186 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1482	135667..134186	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000008

MDM10 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MDM10

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MDM10]

1)	Clark MW, et al. (1994) Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region. Yeast 10(4):535-41
2)	Meisinger C, et al. (2004) The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Dev Cell 7(1):61-71
3)	Meisinger C, et al. (2007) The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J 26(9):2229-39
4)	Kornmann B, et al. (2009) An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 325(5939):477-81

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