Standard Name	SPO7 1
Systematic Name	YAL009W
Feature Type	ORF, Verified
Description	Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation (2, 3, 4)
Name Description	SPOrulation 5

Chromosomal Location	ChrI:135854 to 136633 | ORF Map | GBrowse
	Genetic position: -4 cM

	View Computational GO annotations for SPO7
Molecular Function
Manually curated	contributes_to phosphoprotein phosphatase activity (IDA)
Biological Process
Manually curated	negative regulation of phospholipid biosynthetic process (IGI) nuclear envelope organization (IMP)
Cellular Component
Manually curated	integral to membrane (IDA, ISM) Nem1-Spo7 phosphatase complex (IPI)

Classical genetics
conditional	sporulation efficiency: absent sporulation efficiency: decreased
null	endoplasmic reticulum morphology: abnormal meiosis: abnormal nuclear morphology: abnormal nucleolar morphology: abnormal resistance to bortezomib: decreased sporulation efficiency: decreased
Large-scale survey
null	UV resistance: decreased acid pH resistance: decreased budding pattern: abnormal cell shape: abnormal cell size: increased proton accumulation: decreased competitive fitness: decreased haploinsufficient heat sensitivity: increased hyperosmotic stress resistance: decreased lipid particle morphology: abnormal resistance to mefloquine: decreased resistance to pyrrolidine dithiocarbamate: decreased resistance to ethanol: decreased resistance to calcium dichloride: decreased resistance to oleate: decreased resistance to caffeine: decreased resistance to sirolimus: decreased resistance to L-canavanine: increased resistance to methyl methanesulfonate: decreased respiratory growth: absent sporulation: decreased sporulation efficiency: decreased stress resistance: decreased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	58 total interaction(s) for 43 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 2 PCA: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 2 Phenotypic Enhancement: 10 Phenotypic Suppression: 1 Synthetic Growth Defect: 15 Synthetic Lethality: 19
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrI:135854 to 136633 | ORF Map | GBrowse
	Genetic position: -4 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..780 135854..136633 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000007