SGD Colleagues

Sherif Abou Elela

E-mail Address
Position	Professor
Profession	Molecular Biologist
Organization	Universite de Sherbrooke
Address	1300 12 Av nord Facult de Medicine Universit de Sherbrooke Dp. de microbiologie et d'infectiologie Sherbrooke , QC J1H 5N4 Canada
Work phone	819 564 5275
Fax	819 564 5392
Web Page(s)	http://www.med.usherbrooke.ca/abouelela/
Members of my Lab	Larose Stephanie Mathieu Catala Ghada Ghazal Dongling Ge Jules Gagnon Mathieu Durant Mathieu Lavoie Julie Parenteau Mon Wu

Keywords	RNA binding RNA processing RNase III dimerization dsRBD dsRNA nucleases protein interaction two-hybrid Rnt1p

Research Topics	Translation and protein synthesis RNA processing/metabolism Cell cycle Metabolism and metabolic regulation Protein trafficking, localization and degradation Protein structure/folding Functional genomics/proteomics

Research Interests	We are interested in how dsRNAs are recognized by cellular proteins and how they are regulated in the cell to achieve a specific function. Using a homolog of RNase III from yeast (Rnt1) we are studying the recognition and metabolism of double-stranded RNA. Rnt1 contains a conserved dsRNA binding domain and can specifically cleave duplex RNA. Using yeast as a simple model we are able to characterize the basic features that influence dsRNA recognition and elucidate mechanisms of gene regulation that involve dsRNases.

Research Interests

We are interested in how dsRNAs are recognized by cellular proteins and how they are regulated in the cell to achieve a specific function. Using a homolog of RNase III from yeast (Rnt1) we are studying the recognition and metabolism of double-stranded RNA. Rnt1 contains a conserved dsRNA binding domain and can specifically cleave duplex RNA. Using yeast as a simple model we are able to characterize the basic features that influence dsRNA recognition and elucidate mechanisms of gene regulation that involve dsRNases.

Last Update	2007-09-25

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.