Ontology: Molecular Function (GO:0000297)

Definition: Catalysis of the transfer of spermine from one side of the membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication.

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term spermine transmembrane transporter activity (4 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	spermine transmembrane transporter activity	4
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term spermine transmembrane transporter activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

spermine transmembrane transporter activity      4 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
TPO1/YLL028W	IMP: Inferred from Mutant Phenotype Assigned on 2002-11-27	manually curated	Tomitori H, et al.  (2001) Multiple polyamine transport systems on the vacuolar membrane in yeast. Biochem J 353(Pt 3):681-8	SGD
	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2008-03-11	manually curated	Uemura T, et al.  (2005) Characteristics of the polyamine transporter TPO1 and regulation of its activity and cellular localization by phosphorylation. J Biol Chem 280(10):9646-52	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2008-02-20	manually curated	Tomitori H, et al.  (1999) Identification of a gene for a polyamine transport protein in yeast. J Biol Chem 274(6):3265-7	SGD
TPO2/YGR138C	IMP: Inferred from Mutant Phenotype Assigned on 2002-11-27	manually curated	Tomitori H, et al.  (2001) Multiple polyamine transport systems on the vacuolar membrane in yeast. Biochem J 353(Pt 3):681-8	SGD
TPO3/YPR156C	IMP: Inferred from Mutant Phenotype Assigned on 2002-11-27	manually curated	Tomitori H, et al.  (2001) Multiple polyamine transport systems on the vacuolar membrane in yeast. Biochem J 353(Pt 3):681-8	SGD
TPO4/YOR273C	IMP: Inferred from Mutant Phenotype Assigned on 2002-11-27	manually curated	Tomitori H, et al.  (2001) Multiple polyamine transport systems on the vacuolar membrane in yeast. Biochem J 353(Pt 3):681-8	SGD

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