Ontology: Molecular Function (GO:0000981)

Definition: Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term sequence-specific DNA binding RNA polymerase II transcription factor activity (71 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	sequence-specific DNA binding RNA polymerase II transcription factor activity	20
High-throughput	none	none
Computational (download data)	sequence-specific DNA binding RNA polymerase II transcription factor activity	56

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term sequence-specific DNA binding RNA polymerase II transcription factor activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

sequence-specific DNA binding RNA polymerase II transcription factor activity      71 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ARG81/YML099C	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ARO80/YDR421W	ISS: Inferred from Sequence or structural Similarity with SGD:GAL4 Assigned on 2013-04-30	manually curated	Iraqui I, et al.  (1999) Transcriptional induction by aromatic amino acids in Saccharomyces cerevisiae. Mol Cell Biol 19(5):3360-71	SGD
	IDA: Inferred from Direct Assay Assigned on 2013-05-22	manually curated	Lee K and Hahn JS  (2013) Interplay of Aro80 and GATA activators in regulation of genes for catabolism of aromatic amino acids in Saccharomyces cerevisiae. Mol Microbiol ()	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ASG1/YIL130W	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BAS1/YKR099W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2012-01-20	manually curated	Daignan-Fornier B and Fink GR  (1992) Coregulation of purine and histidine biosynthesis by the transcriptional activators BAS1 and BAS2. Proc Natl Acad Sci U S A 89(15):6746-50	SGD
CAT8/YMR280C	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CEP3/YMR168C	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CHA4/YLR098C	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
DAL80/YKR034W	IDA: Inferred from Direct Assay Assigned on 2011-12-22	manually curated	Cunningham TS, et al.  (1994) The UGA4 UASNTR site required for GLN3-dependent transcriptional activation also mediates DAL80-responsive regulation and DAL80 protein binding in Saccharomyces cerevisiae. J Bacteriol 176(15):4718-25	SGD
DAL81/YIR023W	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ECM22/YLR228C	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
EDS1/YBR033W	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ERT1/YBR239C	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
GAL4/YPL248C	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
GAT2/YMR136W	ISA: Inferred from Sequence Alignment with SGD:DAL80 Assigned on 2012-03-09	manually curated	Cox KH, et al.  (1999) Genome-wide transcriptional analysis in S. cerevisiae by mini-array membrane hybridization. Yeast 15(8):703-13	SGD
GSM1/YJL103C	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
GZF3/YJL110C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2011-12-23	manually curated	Georis I, et al.  (2009) The yeast GATA factor Gat1 occupies a central position in nitrogen catabolite repression-sensitive gene activation. Mol Cell Biol 29(13):3803-15	SGD
HAA1/YPR008W	IDA: Inferred from Direct Assay Assigned on 2011-12-12	manually curated	Mira NP, et al.  (2011) Identification of a DNA-binding site for the transcription factor Haa1, required for Saccharomyces cerevisiae response to acetic acid stress. Nucleic Acids Res 39(16):6896-907	SGD
HAC1/YFL031W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2012-01-13	manually curated	Mori K, et al.  (1996) Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway. Genes Cells 1(9):803-17	SGD
	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2012-01-13	manually curated	Schroder M, et al.  (2004) The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase. EMBO J 23(11):2281-92	SGD
HAL9/YOL089C	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
HAP1/YLR256W	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
HOT1/YMR172W	IDA: Inferred from Direct Assay Assigned on 2011-12-14	manually curated	Alepuz PM, et al.  (2001) Stress-induced map kinase Hog1 is part of transcription activation complexes. Mol Cell 7(4):767-77	SGD
LEU3/YLR451W	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
LYS14/YDR034C	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MAL13/YGR288W	IEA: Inferred from Electronic Annotation with EBI:IPR001138, EBI:IPR020448 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MAL33/YBR297W	IEA: Inferred from Electronic Annotation with EBI:IPR020448, EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
OAF1/YAL051W	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
OAF3/YKR064W	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PDR1/YGL013C	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PDR3/YBL005W	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PDR8/YLR266C	ISA: Inferred from Sequence Alignment with SGD:YRR1 Assigned on 2011-09-17	manually curated	Le Crom S, et al.  (2002) New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system. Mol Cell Biol 22(8):2642-9	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001138 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

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