Ontology: Cellular Component (GO:0000932)

Definition: A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci.

Synonyms: cytoplasmic foci; P body; P-body

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term cytoplasmic mRNA processing body (27 genes) or to its variants containing one or more qualifiers (5 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	colocalizes_with: cytoplasmic mRNA processing body	5
	cytoplasmic mRNA processing body	26
High-throughput	none	none
Computational (download data)	cytoplasmic mRNA processing body	14

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term cytoplasmic mRNA processing body or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

cytoplasmic mRNA processing body      27 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
CCR4/YAL021C	IDA: Inferred from Direct Assay Assigned on 2008-08-06	manually curated	Reijns MA, et al.  (2008) A role for Q/N-rich aggregation-prone regions in P-body localization. J Cell Sci 121(Pt 15):2463-72	SGD
DCP1/YOL149W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2003-07-18	manually curated	Sheth U and Parker R  (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300(5620):805-8	SGD
	IEA: Inferred from Electronic Annotation with EBI:SL-0230 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
DCP2/YNL118C	IDA: Inferred from Direct Assay Assigned on 2003-07-18	manually curated	Sheth U and Parker R  (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300(5620):805-8	SGD
	IEA: Inferred from Electronic Annotation with EBI:SL-0230 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
DCS1/YLR270W	IDA: Inferred from Direct Assay Assigned on 2006-09-26	manually curated	Malys N and McCarthy JE  (2006) Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies. J Mol Biol 363(2):370-82	SGD
	IEA: Inferred from Electronic Annotation with EBI:SL-0230 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
DCS2/YOR173W	IDA: Inferred from Direct Assay Assigned on 2006-09-26	manually curated	Malys N and McCarthy JE  (2006) Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies. J Mol Biol 363(2):370-82	SGD
	IEA: Inferred from Electronic Annotation with EBI:SL-0230 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
DHH1/YDL160C	IDA: Inferred from Direct Assay Assigned on 2003-07-18	manually curated	Sheth U and Parker R  (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300(5620):805-8	SGD
	IDA: Inferred from Direct Assay Assigned on 2008-08-06	manually curated	Reijns MA, et al.  (2008) A role for Q/N-rich aggregation-prone regions in P-body localization. J Cell Sci 121(Pt 15):2463-72	SGD
	IEA: Inferred from Electronic Annotation with EBI:SL-0230 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
EBS1/YDR206W	IDA: Inferred from Direct Assay Assigned on 2008-01-13	manually curated	Luke B, et al.  (2007) Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay. Nucleic Acids Res 35(22):7688-97	SGD
EDC3/YEL015W	IDA: Inferred from Direct Assay Assigned on 2004-03-22	manually curated	Kshirsagar M and Parker R  (2004) Identification of Edc3p as an enhancer of mRNA decapping in Saccharomyces cerevisiae. Genetics 166(2):729-39	SGD
	IEA: Inferred from Electronic Annotation with EBI:SL-0230 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
GIS2/YNL255C	IDA: Inferred from Direct Assay Assigned on 2013-01-09	manually curated	Rojas M, et al.  (2012) Yeast Gis2 and Its Human Ortholog CNBP Are Novel Components of Stress-Induced RNP Granules. PLoS One 7(12):e52824	SGD
HEK2/YBL032W	IDA: Inferred from Direct Assay Assigned on 2011-01-18	manually curated	Mauchi N, et al.  (2010) Stability Control of MTL1 mRNA by the RNA-Binding Protein Khd1p in Yeast. Cell Struct Funct 35(2):95-105	SGD
	IEA: Inferred from Electronic Annotation with EBI:SL-0230 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
IGO1/YNL157W	IDA: Inferred from Direct Assay Assigned on 2010-06-23	manually curated	Talarek N, et al.  (2010) Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway. Mol Cell 38(3):345-55	SGD
LSM1/YJL124C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2003-07-18	manually curated	Sheth U and Parker R  (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300(5620):805-8	SGD
	IDA: Inferred from Direct Assay Assigned on 2008-08-06	manually curated	Reijns MA, et al.  (2008) A role for Q/N-rich aggregation-prone regions in P-body localization. J Cell Sci 121(Pt 15):2463-72	SGD
	IEA: Inferred from Electronic Annotation with EBI:SL-0230 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
LSM2/YBL026W	IDA: Inferred from Direct Assay Assigned on 2008-08-06	manually curated	Reijns MA, et al.  (2008) A role for Q/N-rich aggregation-prone regions in P-body localization. J Cell Sci 121(Pt 15):2463-72	SGD
LSM4/YER112W	IDA: Inferred from Direct Assay Assigned on 2008-08-06	manually curated	Reijns MA, et al.  (2008) A role for Q/N-rich aggregation-prone regions in P-body localization. J Cell Sci 121(Pt 15):2463-72	SGD
LSM6/YDR378C	IDA: Inferred from Direct Assay Assigned on 2008-08-06	manually curated	Reijns MA, et al.  (2008) A role for Q/N-rich aggregation-prone regions in P-body localization. J Cell Sci 121(Pt 15):2463-72	SGD
NGR1/YBR212W	IDA: Inferred from Direct Assay Assigned on 2006-12-14	manually curated	Jang LT, et al.  (2006) Determinants of Rbp1p localization in specific cytoplasmic mRNA-processing foci, P-bodies. J Biol Chem 281(39):29379-90	SGD
PAT1/YCR077C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2003-07-18	manually curated	Sheth U and Parker R  (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300(5620):805-8	SGD
	IEA: Inferred from Electronic Annotation with EBI:SL-0230 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
PBY1/YBR094W	IDA: Inferred from Direct Assay Assigned on 2007-02-20	manually curated	Sweet TJ, et al.  (2007) Microtubule disruption stimulates P-body formation. RNA 13(4):493-502	SGD
	IEA: Inferred from Electronic Annotation with EBI:SL-0230 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
POP2/YNR052C	IDA: Inferred from Direct Assay Assigned on 2008-08-06	manually curated	Reijns MA, et al.  (2008) A role for Q/N-rich aggregation-prone regions in P-body localization. J Cell Sci 121(Pt 15):2463-72	SGD
RPB4/YJL140W	IDA: Inferred from Direct Assay Assigned on 2006-11-08	manually curated	Lotan R, et al.  (2005) The RNA polymerase II subunit Rpb4p mediates decay of a specific class of mRNAs. Genes Dev 19(24):3004-16	SGD
	IEA: Inferred from Electronic Annotation with EBI:SL-0230 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
RPB7/YDR404C	IDA: Inferred from Direct Assay Assigned on 2008-03-31	manually curated	Lotan R, et al.  (2007) The Rpb7p subunit of yeast RNA polymerase II plays roles in the two major cytoplasmic mRNA decay mechanisms. J Cell Biol 178(7):1133-43	SGD
	IEA: Inferred from Electronic Annotation with EBI:SL-0230 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
SBP1/YHL034C	IDA: Inferred from Direct Assay Assigned on 2007-12-07	manually curated	Segal SP, et al.  (2006) Sbp1p affects translational repression and decapping in Saccharomyces cerevisiae. Mol Cell Biol 26(13):5120-30	SGD
SCD6/YPR129W	IDA: Inferred from Direct Assay Assigned on 2012-03-19	manually curated	Rajyaguru P, et al.  (2012) Scd6 Targets eIF4G to Repress Translation: RGG Motif Proteins as a Class of eIF4G-Binding Proteins. Mol Cell 45(2):244-54	SGD
SSD1/YDR293C	IDA: Inferred from Direct Assay Assigned on 2011-04-15	manually curated	Jansen JM, et al.  (2009) Cbk1 regulation of the RNA-binding protein Ssd1 integrates cell fate with translational control. Curr Biol 19(24):2114-20	SGD
	IDA: Inferred from Direct Assay Assigned on 2011-03-15	manually curated	Kurischko C, et al.  (2011) The yeast Cbk1 kinase regulates mRNA localization via the mRNA-binding protein Ssd1. J Cell Biol 192(4):583-98	SGD
TIS11/YLR136C	IEA: Inferred from Electronic Annotation with EBI:SL-0230 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
VTS1/YOR359W	IDA: Inferred from Direct Assay Assigned on 2008-07-15	manually curated	Rendl LM, et al.  (2008) S. cerevisiae Vts1p induces deadenylation-dependent transcript degradation and interacts with the Ccr4p-Pop2p-Not deadenylase complex. RNA 14(7):1328-36	SGD
XRN1/YGL173C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2003-07-18	manually curated	Sheth U and Parker R  (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300(5620):805-8	SGD
	IEA: Inferred from Electronic Annotation with EBI:SL-0230 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB

colocalizes_with: cytoplasmic mRNA processing body      5 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
RPM2/YML091C	IDA: Inferred from Direct Assay Assigned on 2007-02-08	manually curated	Stribinskis V and Ramos KS  (2007) Rpm2p, a protein subunit of mitochondrial RNase P, physically and genetically interacts with cytoplasmic processing bodies. Nucleic Acids Res 35(4):1301-11	SGD
SMY2/YBR172C	IDA: Inferred from Direct Assay Assigned on 2011-03-21	manually curated	Georgiev A, et al.  (2007) Binding specificities of the GYF domains from two Saccharomyces cerevisiae Paralogs. Protein Eng Des Sel 20(9):443-52	SGD
SYH1/YPL105C	IDA: Inferred from Direct Assay Assigned on 2011-03-21	manually curated	Georgiev A, et al.  (2007) Binding specificities of the GYF domains from two Saccharomyces cerevisiae Paralogs. Protein Eng Des Sel 20(9):443-52	SGD
YGR109W-A	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2012-06-08	manually curated	Larsen LS, et al.  (2007) Ty3 capsid mutations reveal early and late functions of the amino-terminal domain. J Virol 81(13):6957-72	SGD
YIL082W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2012-06-08	manually curated	Larsen LS, et al.  (2007) Ty3 capsid mutations reveal early and late functions of the amino-terminal domain. J Virol 81(13):6957-72	SGD

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