Ontology: Biological Process (GO:0009306)

Definition: The controlled release of proteins from a cell.

Synonyms: glycoprotein secretion; protein secretion during cell fate commitment; protein secretion resulting in cell fate commitment

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term protein secretion (8 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	protein secretion	8
High-throughput	none	none
Computational (download data)	protein secretion	1

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term protein secretion or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

protein secretion      8 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ACT1/YFL039C	IGI: Inferred from Genetic Interaction with SGD:TPM2, SGD:TPM1, IMP: Inferred from Mutant Phenotype Assigned on 2013-04-10	manually curated	Karpova TS, et al.  (2000) Role of actin and Myo2p in polarized secretion and growth of Saccharomyces cerevisiae. Mol Biol Cell 11(5):1727-37	SGD
BUG1/YDL099W	IMP: Inferred from Mutant Phenotype Assigned on 2010-03-01	manually curated	Duran JM, et al.  (2010) Unconventional secretion of Acb1 is mediated by autophagosomes. J Cell Biol 188(4):527-36	SGD
DDI1/YER143W	IMP: Inferred from Mutant Phenotype Assigned on 2011-03-30	manually curated	White RE, et al.  (2011) The retroviral proteinase active site and the N-terminus of Ddi1 are required for repression of protein secretion. FEBS Lett 585(1):139-42	SGD
GRH1/YDR517W	IMP: Inferred from Mutant Phenotype Assigned on 2010-03-01	manually curated	Duran JM, et al.  (2010) Unconventional secretion of Acb1 is mediated by autophagosomes. J Cell Biol 188(4):527-36	SGD
NCE101/YJL205C	IGI: Inferred from Genetic Interaction Assigned on 2002-09-27	manually curated	Cleves AE, et al.  (1996) A new pathway for protein export in Saccharomyces cerevisiae. J Cell Biol 133(5):1017-26	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR024242 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
NCE102/YPR149W	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2002-09-27	manually curated	Cleves AE, et al.  (1996) A new pathway for protein export in Saccharomyces cerevisiae. J Cell Biol 133(5):1017-26	SGD
SCD5/YOR329C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2002-08-20	manually curated	Nelson KK, et al.  (1996) SCD5, a suppressor of clathrin deficiency, encodes a novel protein with a late secretory function in yeast. Mol Biol Cell 7(2):245-60	SGD
YSY6/YBR162W-A	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-09-27	manually curated	Schroder K, et al.  (1999) Control of glycosylation of MHC class II-associated invariant chain by translocon-associated RAMP4. EMBO J 18(17):4804-15	SGD

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