GO term: biotin biosynthetic process 
Ontology: Biological Process (GO:0009102)
Definition: The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.
Synonyms: biotin anabolism; biotin biosynthesis; biotin formation; biotin synthesis; vitamin B7 biosynthesis; vitamin B7 biosynthetic process; vitamin H biosynthesis; vitamin H biosynthetic process
View Ontology:
(graph) | 
(text)
Definition: The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.
Synonyms: biotin anabolism; biotin biosynthesis; biotin formation; biotin synthesis; vitamin B7 biosynthesis; vitamin B7 biosynthetic process; vitamin H biosynthesis; vitamin H biosynthetic process
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
biotin biosynthetic process (10 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | biotin biosynthetic process | 10 |
| High-throughput | none | none |
| Computational (download data) | biotin biosynthetic process | 3 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
biotin biosynthetic process or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| biotin biosynthetic process 10 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| BIO1/YAR070W-A | IGI: Inferred from Genetic Interaction with SGD:BIO6, ISS: Inferred from Sequence or structural Similarity with EBI:P53559 Assigned on 2007-12-28 |
manually curated | Hall C and Dietrich FS (2007) The Reacquisition of Biotin Prototrophy in Saccharomyces cerevisiae Involved Horizontal Gene Transfer, Gene Duplication and Gene Clustering. Genetics 177(4):2293-307 |
SGD |
| BIO2/YGR286C | IMP: Inferred from Mutant Phenotype Assigned on 2010-05-13 |
manually curated | Phalip V, et al. (1999) Cloning of Schizosaccharomyces pombe bio2 by heterologous complementation of a Saccharomyces cerevisiae mutant. Curr Microbiol 39(6):348-0350 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR002684 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0093 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with UniPathway:UPA00078 Last Updated 2013-03-02 |
computational | UniProt-GOA (2012) Gene Ontology annotation based on UniPathway vocabulary mapping. |
UniPathway | |
| BIO3/YNR058W | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2002-09-27 |
manually curated | Phalip V, et al. (1999) Characterization of the biotin biosynthesis pathway in Saccharomyces cerevisiae and evidence for a cluster containing BIO5, a novel gene involved in vitamer uptake. Gene 232(1):43-51 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR005815 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0093 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with UniPathway:UPA00078 Last Updated 2013-03-02 |
computational | UniProt-GOA (2012) Gene Ontology annotation based on UniPathway vocabulary mapping. |
UniPathway | |
| BIO4/YNR057C | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2002-09-27 |
manually curated | Phalip V, et al. (1999) Characterization of the biotin biosynthesis pathway in Saccharomyces cerevisiae and evidence for a cluster containing BIO5, a novel gene involved in vitamer uptake. Gene 232(1):43-51 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR004472 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0093 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with UniPathway:UPA00078 Last Updated 2013-03-02 |
computational | UniProt-GOA (2012) Gene Ontology annotation based on UniPathway vocabulary mapping. |
UniPathway | |
| BIO5/YNR056C | IMP: Inferred from Mutant Phenotype Assigned on 2002-09-27 |
manually curated | Phalip V, et al. (1999) Characterization of the biotin biosynthesis pathway in Saccharomyces cerevisiae and evidence for a cluster containing BIO5, a novel gene involved in vitamer uptake. Gene 232(1):43-51 |
SGD |
| BIO6/YAR069W-A | IMP: Inferred from Mutant Phenotype Assigned on 2005-11-09 |
manually curated | Wu H, et al. (2005) Identification and characterization of a novel biotin biosynthesis gene in Saccharomyces cerevisiae. Appl Environ Microbiol 71(11):6845-55 |
SGD |
| IGI: Inferred from Genetic Interaction with SGD:BIO1 Assigned on 2007-12-17 |
manually curated | Hall C and Dietrich FS (2007) The Reacquisition of Biotin Prototrophy in Saccharomyces cerevisiae Involved Horizontal Gene Transfer, Gene Duplication and Gene Clustering. Genetics 177(4):2293-307 |
SGD | |
| BIO7/YHR214W-G | IGI: Inferred from Genetic Interaction with SGD:BIO6, ISA: Inferred from Sequence Alignment with EBI:P53559 Assigned on 2008-04-17 |
manually curated | Hall C and Dietrich FS (2007) The Reacquisition of Biotin Prototrophy in Saccharomyces cerevisiae Involved Horizontal Gene Transfer, Gene Duplication and Gene Clustering. Genetics 177(4):2293-307 |
SGD |
| BIO8/YHR214W-F | IGI: Inferred from Genetic Interaction with SGD:BIO1 Assigned on 2008-04-17 |
manually curated | Hall C and Dietrich FS (2007) The Reacquisition of Biotin Prototrophy in Saccharomyces cerevisiae Involved Horizontal Gene Transfer, Gene Duplication and Gene Clustering. Genetics 177(4):2293-307 |
SGD |
| ISA1/YLL027W | IGI: Inferred from Genetic Interaction with SGD:ISA2, IMP: Inferred from Mutant Phenotype Assigned on 2009-11-12 |
manually curated | Muhlenhoff U, et al. (2007) The ISC [corrected] proteins Isa1 and Isa2 are required for the function but not for the de novo synthesis of the Fe/S clusters of biotin synthase in Saccharomyces cerevisiae. Eukaryot Cell 6(3):495-504 |
SGD |
| ISA2/YPR067W | IGI: Inferred from Genetic Interaction with SGD:ISA1, IMP: Inferred from Mutant Phenotype Assigned on 2007-02-08 |
manually curated | Muhlenhoff U, et al. (2007) The ISC [corrected] proteins Isa1 and Isa2 are required for the function but not for the de novo synthesis of the Fe/S clusters of biotin synthase in Saccharomyces cerevisiae. Eukaryot Cell 6(3):495-504 |
SGD |
