Ontology: Biological Process (GO:0000910)

Definition: The division of the cytoplasm and the plasma membrane of a cell and its separation into two daughter cells.

Synonyms: cytokinesis involved in cell cycle; cell cycle cytokinesis

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term cytokinesis (35 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	cytokinesis	34
High-throughput	none	none
Computational (download data)	cytokinesis	1

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term cytokinesis or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

cytokinesis      35 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ACT1/YFL039C	IDA: Inferred from Direct Assay Assigned on 2006-09-18	manually curated	Bi E, et al.  (1998) Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis. J Cell Biol 142(5):1301-12	SGD
ARK1/YNL020C	TAS: Traceable Author Statement Assigned on 2001-01-19	manually curated	Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
ASE1/YOR058C	IEA: Inferred from Electronic Annotation with EBI:IPR007145 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
AXL2/YIL140W	IMP: Inferred from Mutant Phenotype Assigned on 2013-02-28	manually curated	Roemer T, et al.  (1996) Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein. Genes Dev 10(7):777-93	SGD
BNI5/YNL166C	IGI: Inferred from Genetic Interaction Assigned on 2002-09-26	manually curated	Lee PR, et al.  (2002) Bni5p, a septin-interacting protein, is required for normal septin function and cytokinesis in Saccharomyces cerevisiae. Mol Cell Biol 22(19):6906-20	SGD
BUD3/YCL014W	IMP: Inferred from Mutant Phenotype Assigned on 2005-06-02	manually curated	Bailly E, et al.  (2003) Differential cellular localization among mitotic cyclins from Saccharomyces cerevisiae: a new role for the axial budding protein Bud3 in targeting Clb2 to the mother-bud neck. J Cell Sci 116(Pt 20):4119-30	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2013-05-22	manually curated	Roemer T, et al.  (1996) Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein. Genes Dev 10(7):777-93	SGD
CDC10/YCR002C	IDA: Inferred from Direct Assay Assigned on 2011-10-07	manually curated	Dobbelaere J, et al.  (2003) Phosphorylation-dependent regulation of septin dynamics during the cell cycle. Dev Cell 4(3):345-57	SGD
CDC11/YJR076C	IMP: Inferred from Mutant Phenotype Assigned on 2011-10-07	manually curated	Hartwell LH  (1971) Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis. Exp Cell Res 69(2):265-76	SGD
CDC12/YHR107C	IDA: Inferred from Direct Assay Assigned on 2011-10-07	manually curated	Dobbelaere J, et al.  (2003) Phosphorylation-dependent regulation of septin dynamics during the cell cycle. Dev Cell 4(3):345-57	SGD
CDC15/YAR019C	IMP: Inferred from Mutant Phenotype Assigned on 2002-09-18	manually curated	Menssen R, et al.  (2001) Asymmetric spindle pole localization of yeast Cdc15 kinase links mitotic exit and cytokinesis. Curr Biol 11(5):345-50	SGD
CDC3/YLR314C	IDA: Inferred from Direct Assay Assigned on 2011-10-07	manually curated	Dobbelaere J, et al.  (2003) Phosphorylation-dependent regulation of septin dynamics during the cell cycle. Dev Cell 4(3):345-57	SGD
CHS2/YBR038W	IMP: Inferred from Mutant Phenotype Assigned on 2004-10-13	manually curated	Schmidt M, et al.  (2002) In budding yeast, contraction of the actomyosin ring and formation of the primary septum at cytokinesis depend on each other. J Cell Sci 115(Pt 2):293-302	SGD
	IGI: Inferred from Genetic Interaction with SGD:INN1, SGD:CYK3 Assigned on 2013-02-12	manually curated	Devrekanli A, et al.  (2012) Inn1 and Cyk3 regulate chitin synthase during cytokinesis in budding yeasts. J Cell Sci 125(Pt 22):5453-66	SGD
CHS3/YBR023C	TAS: Traceable Author Statement Assigned on 2004-10-14	manually curated	Cid VJ, et al.  (1995) Molecular basis of cell integrity and morphogenesis in Saccharomyces cerevisiae. Microbiol Rev 59(3):345-86	SGD
CLA4/YNL298W	TAS: Traceable Author Statement Assigned on 2001-01-19	manually curated	Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
CYK3/YDL117W	IPI: Inferred from Physical Interaction with SGD:INN1, SGD:HOF1, SGD:SHO1 Assigned on 2012-06-20	manually curated	Labedzka K, et al.  (2012) Sho1p connects the plasma membrane with proteins of the cytokinesis network through multiple isomeric interaction states. J Cell Sci 125(Pt 17):4103-13	SGD
	IGI: Inferred from Genetic Interaction with SGD:CHS2, SGD:INN1 Assigned on 2013-02-12	manually curated	Devrekanli A, et al.  (2012) Inn1 and Cyk3 regulate chitin synthase during cytokinesis in budding yeasts. J Cell Sci 125(Pt 22):5453-66	SGD
DBF2/YGR092W	IMP: Inferred from Mutant Phenotype Assigned on 2013-01-26	manually curated	Oh Y, et al.  (2012) Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast. Mol Biol Cell 23(13):2445-56	SGD
EGT2/YNL327W	IMP: Inferred from Mutant Phenotype Assigned on 2002-12-09	manually curated	Kovacech B, et al.  (1996) EGT2 gene transcription is induced predominantly by Swi5 in early G1. Mol Cell Biol 16(7):3264-74	SGD
ELM1/YKL048C	TAS: Traceable Author Statement Assigned on 2001-01-19	manually curated	Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
END3/YNL084C	TAS: Traceable Author Statement Assigned on 2001-01-19	manually curated	Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
HOF1/YMR032W	IGI: Inferred from Genetic Interaction with SGD:SHO1, IPI: Inferred from Physical Interaction with SGD:CYK3, SGD:SHO1, SGD:INN1 Assigned on 2012-06-20	manually curated	Labedzka K, et al.  (2012) Sho1p connects the plasma membrane with proteins of the cytokinesis network through multiple isomeric interaction states. J Cell Sci 125(Pt 17):4103-13	SGD
INN1/YNL152W	IPI: Inferred from Physical Interaction with SGD:CYK3, SGD:HOF1, SGD:SHO1 Assigned on 2012-06-20	manually curated	Labedzka K, et al.  (2012) Sho1p connects the plasma membrane with proteins of the cytokinesis network through multiple isomeric interaction states. J Cell Sci 125(Pt 17):4103-13	SGD
	IGI: Inferred from Genetic Interaction with SGD:CYK3, SGD:CHS2, IMP: Inferred from Mutant Phenotype Assigned on 2013-02-12	manually curated	Devrekanli A, et al.  (2012) Inn1 and Cyk3 regulate chitin synthase during cytokinesis in budding yeasts. J Cell Sci 125(Pt 22):5453-66	SGD
IQG1/YPL242C	IMP: Inferred from Mutant Phenotype Assigned on 2003-05-07	manually curated	Lippincott J and Li R  (1998) Sequential assembly of myosin II, an IQGAP-like protein, and filamentous actin to a ring structure involved in budding yeast cytokinesis. J Cell Biol 140(2):355-66	SGD
MLC1/YGL106W	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:MYO1, SGD:IQG1 Assigned on 2006-09-19	manually curated	Luo J, et al.  (2004) Identification and functional analysis of the essential and regulatory light chains of the only type II myosin Myo1p in Saccharomyces cerevisiae. J Cell Biol 165(6):843-55	SGD
MYO1/YHR023W	IMP: Inferred from Mutant Phenotype Assigned on 2006-09-18	manually curated	Watts FZ, et al.  (1987) The yeast MYO1 gene encoding a myosin-like protein required for cell division. EMBO J 6(11):3499-505	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2006-09-18	manually curated	Bi E, et al.  (1998) Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis. J Cell Biol 142(5):1301-12	SGD
	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2006-09-18	manually curated	Tolliday N, et al.  (2003) Direct evidence for a critical role of myosin II in budding yeast cytokinesis and the evolvability of new cytokinetic mechanisms in the absence of myosin II. Mol Biol Cell 14(2):798-809	SGD
PAN1/YIR006C	IMP: Inferred from Mutant Phenotype Assigned on 2008-09-15	manually curated	Tang HY and Cai M  (1996) The EH-domain-containing protein Pan1 is required for normal organization of the actin cytoskeleton in Saccharomyces cerevisiae. Mol Cell Biol 16(9):4897-914	SGD
PRK1/YIL095W	TAS: Traceable Author Statement Assigned on 2001-01-19	manually curated	Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
PWP2/YCR057C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-19	manually curated	Shafaatian R, et al.  (1996) PWP2, a member of the WD-repeat family of proteins, is an essential Saccharomyces cerevisiae gene involved in cell separation. Mol Gen Genet 252(1-2):101-14	SGD
ROT1/YMR200W	IMP: Inferred from Mutant Phenotype Assigned on 2007-07-16	manually curated	Juanes MA, et al.  (2007) Rot1 plays an antagonistic role to Clb2 in actin cytoskeleton dynamics throughout the cell cycle. J Cell Sci 120(Pt 14):2390-401	SGD
SEC4/YFL005W	TAS: Traceable Author Statement Assigned on 2001-01-19	manually curated	Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
SHO1/YER118C	IGI: Inferred from Genetic Interaction with SGD:HOF1, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:HOF1, SGD:CYK3, SGD:INN1 Assigned on 2012-06-19	manually curated	Labedzka K, et al.  (2012) Sho1p connects the plasma membrane with proteins of the cytokinesis network through multiple isomeric interaction states. J Cell Sci 125(Pt 17):4103-13	SGD

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