GO term: leucine biosynthetic process

Ontology: Biological Process (GO:0009098)

Definition: The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.

Synonyms: leucine anabolism; leucine biosynthesis; leucine formation; leucine synthesis

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Annotation Summary

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This table lists the methods used to annotate genes either directly to the term leucine biosynthetic process (7 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	leucine biosynthetic process	4
High-throughput	none	none
Computational (download data)	leucine biosynthetic process	7

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Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Genes Annotated with this Term

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Annotation details for genes that have been directly annotated to the term leucine biosynthetic process or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

leucine biosynthetic process 7 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
BAT1/YHR208W	IEA: Inferred from Electronic Annotation with UniPathway:UPA00048 Last Updated 2013-03-02	computational	UniProt-GOA (2012) Gene Ontology annotation based on UniPathway vocabulary mapping.	UniPathway
BAT2/YJR148W	IEA: Inferred from Electronic Annotation with UniPathway:UPA00048 Last Updated 2013-03-02	computational	UniProt-GOA (2012) Gene Ontology annotation based on UniPathway vocabulary mapping.	UniPathway
LEU1/YGL009C	IMP: Inferred from Mutant Phenotype Assigned on 2013-04-29	manually curated	Hsu YP and Schimmel P (1984) Yeast LEU1. Repression of mRNA levels by leucine and relationship of 5'-noncoding region to that of LEU2. J Biol Chem 259(6):3714-9	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2013-04-29	manually curated	Satyanarayana T, et al. (1968) Biosynthesis of branched-chain amino acids in yeast: correlation of biochemical blocks and genetic lesions in leucine auxotrophs. J Bacteriol 96(6):2012-7	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR004431, EBI:IPR012235, EBI:IPR004430 Last Updated 2013-03-02	computational	DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0432 Last Updated 2013-03-02	computational	UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with UniPathway:UPA00048 Last Updated 2013-03-02	computational	UniProt-GOA (2012) Gene Ontology annotation based on UniPathway vocabulary mapping.	UniPathway
LEU2/YCL018W	IMP: Inferred from Mutant Phenotype Assigned on 2002-08-01	manually curated	Andreadis A, et al. (1982) Nucleotide sequence of yeast LEU2 shows 5'-noncoding region has sequences cognate to leucine. Cell 31(2 Pt 1):319-25	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR004429 Last Updated 2013-03-02	computational	DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0432 Last Updated 2013-03-02	computational	UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with UniPathway:UPA00048 Last Updated 2013-03-02	computational	UniProt-GOA (2012) Gene Ontology annotation based on UniPathway vocabulary mapping.	UniPathway
LEU3/YLR451W	IEA: Inferred from Electronic Annotation with EBI:KW-0432 Last Updated 2013-03-02	computational	UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
LEU4/YNL104C	IGI: Inferred from Genetic Interaction with SGD:LEU9 Assigned on 2013-03-22	manually curated	Casalone E, et al. (2000) Identification by functional analysis of the gene encoding alpha-isopropylmalate synthase II (LEU9) in Saccharomyces cerevisiae. Yeast 16(6):539-45	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR013709, EBI:IPR005668 Last Updated 2013-03-02	computational	DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0432 Last Updated 2013-03-02	computational	UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with UniPathway:UPA00048 Last Updated 2013-03-02	computational	UniProt-GOA (2012) Gene Ontology annotation based on UniPathway vocabulary mapping.	UniPathway
LEU9/YOR108W	IGI: Inferred from Genetic Interaction with SGD:LEU4 Assigned on 2006-08-04	manually curated	Casalone E, et al. (2000) Identification by functional analysis of the gene encoding alpha-isopropylmalate synthase II (LEU9) in Saccharomyces cerevisiae. Yeast 16(6):539-45	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR005668, EBI:IPR013709 Last Updated 2013-03-02	computational	DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0432 Last Updated 2013-03-02	computational	UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with UniPathway:UPA00048 Last Updated 2013-03-02	computational	UniProt-GOA (2012) Gene Ontology annotation based on UniPathway vocabulary mapping.	UniPathway

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