Ontology: Molecular Function (GO:0008565)

Definition: Enables the directed movement of proteins into, out of or within a cell, or between cells.

Synonyms: enzyme transporter activity; holin; protein carrier activity; protein transport chaperone; secretin

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term protein transporter activity (34 genes) or to its variants containing one or more qualifiers (6 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	contributes_to: protein transporter activity	6
	protein transporter activity	23
High-throughput	none	none
Computational (download data)	protein transporter activity	23

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term protein transporter activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

protein transporter activity      34 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
APL1/YJR005W	IEA: Inferred from Electronic Annotation with EBI:IPR016342 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
APL2/YKL135C	IEA: Inferred from Electronic Annotation with EBI:IPR016342 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
APL3/YBL037W	IEA: Inferred from Electronic Annotation with EBI:IPR017104 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
APL4/YPR029C	IEA: Inferred from Electronic Annotation with EBI:IPR017107 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
APL5/YPL195W	IEA: Inferred from Electronic Annotation with EBI:IPR017105 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
APS1/YLR170C	IEA: Inferred from Electronic Annotation with EBI:IPR016635 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
APS2/YJR058C	IEA: Inferred from Electronic Annotation with EBI:IPR016635, EBI:IPR027156 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
APS3/YJL024C	IEA: Inferred from Electronic Annotation with EBI:IPR016635, EBI:IPR027155 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
COG3/YER157W	TAS: Traceable Author Statement Assigned on 2002-10-02	manually curated	Friedmann E, et al.  (2002) YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins. J Biol Chem 277(38):35274-81	SGD
CRM1/YGR218W	IDA: Inferred from Direct Assay Assigned on 2009-10-20	manually curated	Yan C, et al.  (1998) Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor. EMBO J 17(24):7416-29	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2009-10-20	manually curated	Stade K, et al.  (1997) Exportin 1 (Crm1p) is an essential nuclear export factor. Cell 90(6):1041-50	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001494 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CSE1/YGL238W	IEA: Inferred from Electronic Annotation with EBI:IPR001494 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
KAP114/YGL241W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:SPT15 Assigned on 2009-10-20	manually curated	Pemberton LF, et al.  (1999) Nuclear import of the TATA-binding protein: mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting. J Cell Biol 145(7):1407-17	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001494 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
KAP120/YPL125W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2010-11-29	manually curated	Kim KY, et al.  (2010) Yeast Mpk1 cell wall integrity mitogen-activated protein kinase regulates nucleocytoplasmic shuttling of the Swi6 transcriptional regulator. Mol Biol Cell 21(9):1609-19	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001494 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
KAP122/YGL016W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:TOA2 Assigned on 2009-10-23	manually curated	Titov AA and Blobel G  (1999) The karyopherin Kap122p/Pdr6p imports both subunits of the transcription factor IIA into the nucleus. J Cell Biol 147(2):235-46	SGD
KAP123/YER110C	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:RPL25 Assigned on 2009-10-23	manually curated	Schlenstedt G, et al.  (1997) Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus. EMBO J 16(20):6237-49	SGD
	IPI: Inferred from Physical Interaction with SGD:RPS1A Assigned on 2009-10-23	manually curated	Rout MP, et al.  (1997) A distinct nuclear import pathway used by ribosomal proteins. Cell 89(5):715-25	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001494 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
KAP95/YLR347C	IDA: Inferred from Direct Assay Assigned on 2009-10-29	manually curated	Enenkel C, et al.  (1995) Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes. J Biol Chem 270(28):16499-502	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001494, EBI:IPR027140 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
LST4/YKL176C	IDA: Inferred from Direct Assay Assigned on 2002-10-01	manually curated	Roberg KJ, et al.  (1997) Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8. Genetics 147(4):1569-84	SGD
LST7/YGR057C	IDA: Inferred from Direct Assay Assigned on 2002-10-01	manually curated	Roberg KJ, et al.  (1997) Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8. Genetics 147(4):1569-84	SGD
MTR10/YOR160W	IEA: Inferred from Electronic Annotation with EBI:IPR001494 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
NMD5/YJR132W	IMP: Inferred from Mutant Phenotype Assigned on 2009-10-29	manually curated	Ferrigno P, et al.  (1998) Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1. EMBO J 17(19):5606-14	SGD
	IDA: Inferred from Direct Assay Assigned on 2009-10-29	manually curated	Albertini M, et al.  (1998) A novel nuclear import pathway for the transcription factor TFIIS. J Cell Biol 143(6):1447-55	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001494 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PSE1/YMR308C	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:YAP1 Assigned on 2009-10-20	manually curated	Isoyama T, et al.  (2001) Nuclear import of the yeast AP-1-like transcription factor Yap1p is mediated by transport receptor Pse1p, and this import step is not affected by oxidative stress. J Biol Chem 276(24):21863-9	SGD
SEC62/YPL094C	TAS: Traceable Author Statement Assigned on 2003-05-21	manually curated	Romisch K  (1999) Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane. J Cell Sci 112 ( Pt 23)():4185-91	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR004728, EBI:IPR011553 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SEC63/YOR254C	IMP: Inferred from Mutant Phenotype Assigned on 2005-08-08	manually curated	Wang X and Johnsson N  (2005) Protein kinase CK2 phosphorylates Sec63p to stimulate the assembly of the endoplasmic reticulum protein translocation apparatus. J Cell Sci 118(Pt 4):723-32	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR027137 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SEC66/YBR171W	TAS: Traceable Author Statement Assigned on 2003-05-21	manually curated	Romisch K  (1999) Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane. J Cell Sci 112 ( Pt 23)():4185-91	SGD
SEC72/YLR292C	TAS: Traceable Author Statement Assigned on 2003-05-21	manually curated	Romisch K  (1999) Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane. J Cell Sci 112 ( Pt 23)():4185-91	SGD
SRP1/YNL189W	IDA: Inferred from Direct Assay Assigned on 2009-10-29	manually curated	Enenkel C, et al.  (1995) Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes. J Biol Chem 270(28):16499-502	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR024931, EBI:IPR002652 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SXM1/YDR395W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:NSP1, ISS: Inferred from Sequence or structural Similarity with SGD:KAP95 Assigned on 2009-10-29	manually curated	Rosenblum JS, et al.  (1997) A nuclear import pathway for a protein involved in tRNA maturation. J Cell Biol 139(7):1655-61	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001494 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
TIM10/YHR005C-A	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Koehler CM, et al.  (1998) Import of mitochondrial carriers mediated by essential proteins of the intermembrane space. Science 279(5349):369-73	SGD
	IDA: Inferred from Direct Assay Assigned on 2009-11-04	manually curated	Sirrenberg C, et al.  (1998) Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5. Nature 391(6670):912-5	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR027100 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
TIM13/YGR181W	IDA: Inferred from Direct Assay Assigned on 2009-11-04	manually curated	Koehler CM, et al.  (1999) Human deafness dystonia syndrome is a mitochondrial disease. Proc Natl Acad Sci U S A 96(5):2141-6	SGD
	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Leuenberger D, et al.  (1999) Different import pathways through the mitochondrial intermembrane space for inner membrane proteins. EMBO J 18(17):4816-22	SGD
TIM8/YJR135W-A	IDA: Inferred from Direct Assay Assigned on 2009-11-04	manually curated	Koehler CM, et al.  (1999) Human deafness dystonia syndrome is a mitochondrial disease. Proc Natl Acad Sci U S A 96(5):2141-6	SGD
	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Leuenberger D, et al.  (1999) Different import pathways through the mitochondrial intermembrane space for inner membrane proteins. EMBO J 18(17):4816-22	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR027144 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

contributes_to: protein transporter activity      6 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
MDJ2/YNL328C	IGI: Inferred from Genetic Interaction, IPI: Inferred from Physical Interaction Assigned on 2006-03-02	manually curated	Mokranjac D, et al.  (2005) The import motor of the yeast mitochondrial TIM23 preprotein translocase contains two different J proteins, Tim14 and Mdj2. J Biol Chem 280(36):31608-14	SGD
PEP8/YJL053W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2006-04-26	manually curated	Seaman MN, et al.  (1998) A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. J Cell Biol 142(3):665-81	SGD
VPS17/YOR132W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2006-04-26	manually curated	Seaman MN, et al.  (1998) A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. J Cell Biol 142(3):665-81	SGD
VPS29/YHR012W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2006-04-26	manually curated	Seaman MN, et al.  (1998) A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. J Cell Biol 142(3):665-81	SGD
VPS35/YJL154C	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2006-04-26	manually curated	Seaman MN, et al.  (1998) A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. J Cell Biol 142(3):665-81	SGD
VPS5/YOR069W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2006-04-26	manually curated	Seaman MN, et al.  (1998) A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. J Cell Biol 142(3):665-81	SGD

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