Ontology: Cellular Component (GO:0000839)

Definition: A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term Hrd1p ubiquitin ligase ERAD-L complex (4 genes) or to its variants containing one or more qualifiers (2 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	colocalizes_with: Hrd1p ubiquitin ligase ERAD-L complex	2
	Hrd1p ubiquitin ligase ERAD-L complex	4
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term Hrd1p ubiquitin ligase ERAD-L complex or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

colocalizes_with: Hrd1p ubiquitin ligase ERAD-L complex      2 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
DFM1/YDR411C	IDA: Inferred from Direct Assay Assigned on 2011-02-17	manually curated	Stolz A, et al.  (2010) Dfm1 forms distinct complexes with Cdc48 and the ER ubiquitin ligases and is required for ERAD. Traffic 11(10):1363-9	SGD
YOS9/YDR057W	IPI: Inferred from Physical Interaction with SGD:HRD3 Assigned on 2008-02-06	manually curated	Carvalho P, et al.  (2006) Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell 126(2):361-73	SGD

Hrd1p ubiquitin ligase ERAD-L complex      4 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
DER1/YBR201W	IDA: Inferred from Direct Assay Assigned on 2008-02-06	manually curated	Carvalho P, et al.  (2006) Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell 126(2):361-73	SGD
HRD1/YOL013C	IDA: Inferred from Direct Assay Assigned on 2008-02-06	manually curated	Carvalho P, et al.  (2006) Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell 126(2):361-73	SGD
HRD3/YLR207W	IDA: Inferred from Direct Assay Assigned on 2008-02-06	manually curated	Carvalho P, et al.  (2006) Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell 126(2):361-73	SGD
USA1/YML029W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2008-02-06	manually curated	Carvalho P, et al.  (2006) Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell 126(2):361-73	SGD

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