Ontology: Molecular Function (GO:0008353)

Definition: Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats.

Synonyms: [RNA-polymerase]-subunit kinase activity; ATP:DNA-directed RNA polymerase phosphotransferase activity; CTD kinase activity; RNA-polymerase-subunit kinase activity; STK9; RNA polymerase subunit kinase activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term RNA polymerase II carboxy-terminal domain kinase activity (4 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	RNA polymerase II carboxy-terminal domain kinase activity	3
High-throughput	none	none
Computational (download data)	RNA polymerase II carboxy-terminal domain kinase activity	4

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term RNA polymerase II carboxy-terminal domain kinase activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

RNA polymerase II carboxy-terminal domain kinase activity      4 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
CTK1/YKL139W	IEA: Inferred from Electronic Annotation with IUBMB:2.7.11.23 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
KIN28/YDL108W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2011-02-07	manually curated	Hengartner CJ, et al.  (1998) Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases. Mol Cell 2(1):43-53	SGD
	IDA: Inferred from Direct Assay Assigned on 2005-11-02	manually curated	Cismowski MJ, et al.  (1995) KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity. Mol Cell Biol 15(6):2983-92	SGD
	IEA: Inferred from Electronic Annotation with IUBMB:2.7.11.23 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
SGV1/YPR161C	IDA: Inferred from Direct Assay Assigned on 2011-02-07	manually curated	Murray S, et al.  (2001) Phosphorylation of the RNA polymerase II carboxy-terminal domain by the Bur1 cyclin-dependent kinase. Mol Cell Biol 21(13):4089-96	SGD
	IEA: Inferred from Electronic Annotation with IUBMB:2.7.11.23 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
SSN3/YPL042C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2011-02-07	manually curated	Hengartner CJ, et al.  (1998) Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases. Mol Cell 2(1):43-53	SGD
	IEA: Inferred from Electronic Annotation with IUBMB:2.7.11.23 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB

SGD Home About Blog Site Map Help Terms of Use
© Stanford University, Stanford, CA 94305.