Ontology: Molecular Function (GO:0008233)
Definition: Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
Synonyms: hydrolase, acting on peptide bonds; peptide hydrolase activity; protease activity; proteinase activity
View Ontology:
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(text)
Definition: Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
Synonyms: hydrolase, acting on peptide bonds; peptide hydrolase activity; protease activity; proteinase activity
View Ontology:
(graph) |
This table lists the methods used to annotate genes either directly to the term
peptidase activity (159 genes)
or to its variants containing one or more
qualifiers (1 gene). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | contributes_to: peptidase activity | 1 |
| peptidase activity | 53 | |
| High-throughput | none | none |
| Computational (download data) | peptidase activity | 154 |
Links to Additional Annotations:
- View
annotations in multiple organisms using

- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
peptidase activity or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| peptidase activity 159 genes directly annotated to this term |
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|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| AAP1/YHR047C | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| AFG3/YER017C | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| APE1/YKL103C | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| APE2/YKL157W | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| APE3/YBR286W | IEA: Inferred from Electronic Annotation with EBI:IPR007484 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. | InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB | |
| APE4/YHR113W | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| ARX1/YDR101C | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| ATG4/YNL223W | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| ATP23/YNR020C | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| AXL1/YPR122W | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| BAR1/YIL015W | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| CPS1/YJL172W | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| CYM1/YDR430C | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| DAP2/YHR028C | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| DOA4/YDR069C | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| DUG1/YFR044C | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| DUG2/YBR281C | IGI: Inferred from Genetic Interaction with SGD:MET17 Assigned on 2008-08-20 |
manually curated | Ganguli D, et al. (2007) The Alternative Pathway of Glutathione Degradation Is Mediated by a Novel Protein Complex Involving Three New Genes in Saccharomyces cerevisiae. Genetics 175(3):1137-51 | SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB | |
| DUG3/YNL191W | IGI: Inferred from Genetic Interaction with SGD:MET17 Assigned on 2008-08-20 |
manually curated | Ganguli D, et al. (2007) The Alternative Pathway of Glutathione Degradation Is Mediated by a Novel Protein Complex Involving Three New Genes in Saccharomyces cerevisiae. Genetics 175(3):1137-51 | SGD |
| ECM14/YHR132C | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| ESP1/YGR098C | IEA: Inferred from Electronic Annotation with EBI:IPR005314 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. | InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB | |
| FRA1/YLL029W | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| GPI8/YDR331W | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| HSP31/YDR533C | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| HSP32/YPL280W | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| HSP33/YOR391C | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| ICP55/YER078C | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| IMP1/YMR150C | IEA: Inferred from Electronic Annotation with EBI:IPR026730 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. | InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB | |
| IMP2/YMR035W | IEA: Inferred from Electronic Annotation with EBI:IPR026726 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. | InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB | |
| KEX1/YGL203C | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| KEX2/YNL238W | IEA: Inferred from Electronic Annotation with EBI:KW-0645 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. | UniProtKB |
| contributes_to: peptidase activity 1 gene directly annotated to this term |
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|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| SPC2/YML055W | IMP: Inferred from Mutant Phenotype Assigned on 2011-01-13 |
manually curated | Antonin W, et al. (2000) Interactions between Spc2p and other components of the endoplasmic reticulum translocation sites of the yeast Saccharomyces cerevisiae. J Biol Chem 275(44):34068-72 | SGD |



