Ontology: Cellular Component (GO:0000812)

Definition: A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.

Synonyms: SWR-C

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term Swr1 complex (14 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	Swr1 complex	14
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term Swr1 complex or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

Swr1 complex      14 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ACT1/YFL039C	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76	SGD
	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8	SGD
	IDA: Inferred from Direct Assay Assigned on 2006-10-24	manually curated	Wu WH, et al.  (2005) Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange. Nat Struct Mol Biol 12(12):1064-71	SGD
ARP4/YJL081C	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76	SGD
	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8	SGD
	IDA: Inferred from Direct Assay Assigned on 2006-10-24	manually curated	Wu WH, et al.  (2005) Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange. Nat Struct Mol Biol 12(12):1064-71	SGD
ARP6/YLR085C	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76	SGD
	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8	SGD
	IDA: Inferred from Direct Assay Assigned on 2006-10-24	manually curated	Wu WH, et al.  (2005) Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange. Nat Struct Mol Biol 12(12):1064-71	SGD
BDF1/YLR399C	IDA: Inferred from Direct Assay Assigned on 2012-01-19	manually curated	Wu WH, et al.  (2009) N Terminus of Swr1 Binds to Histone H2AZ and Provides a Platform for Subunit Assembly in the Chromatin Remodeling Complex. J Biol Chem 284(10):6200-7	SGD
RVB1/YDR190C	IPI: Inferred from Physical Interaction with SGD:VPS71 Assigned on 2012-03-02	manually curated	Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76	SGD
	IPI: Inferred from Physical Interaction with SGD:SWR1 Assigned on 2012-03-02	manually curated	Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8	SGD
	IDA: Inferred from Direct Assay Assigned on 2006-10-24	manually curated	Wu WH, et al.  (2005) Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange. Nat Struct Mol Biol 12(12):1064-71	SGD
RVB2/YPL235W	IPI: Inferred from Physical Interaction with SGD:VPS71 Assigned on 2012-03-02	manually curated	Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76	SGD
	IPI: Inferred from Physical Interaction with SGD:SWR1 Assigned on 2012-03-02	manually curated	Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8	SGD
	IDA: Inferred from Direct Assay Assigned on 2006-10-24	manually curated	Wu WH, et al.  (2005) Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange. Nat Struct Mol Biol 12(12):1064-71	SGD
SWC3/YAL011W	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76	SGD
	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8	SGD
SWC4/YGR002C	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76	SGD
	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8	SGD
SWC5/YBR231C	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76	SGD
	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8	SGD
SWC7/YLR385C	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76	SGD
SWR1/YDR334W	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76	SGD
	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8	SGD
VPS71/YML041C	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76	SGD
	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8	SGD
VPS72/YDR485C	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76	SGD
	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8	SGD
	IDA: Inferred from Direct Assay Assigned on 2006-10-24	manually curated	Wu WH, et al.  (2005) Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange. Nat Struct Mol Biol 12(12):1064-71	SGD
YAF9/YNL107W	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76	SGD
	IDA: Inferred from Direct Assay Assigned on 2004-04-12	manually curated	Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8	SGD

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